Nanofluidic redox cycling amplification for the selective detection of catechol

Bernhard Wolfrum, Marcel Zevenbergen, Serge Lemay*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

112 Citations (Scopus)


We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.

Original languageEnglish
Pages (from-to)972-977
Number of pages6
JournalAnalytical chemistry
Issue number4
Publication statusPublished - 15 Feb 2008
Externally publishedYes


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