Nanofluidic redox cycling amplification for the selective detection of catechol

Bernhard Wolfrum; Marcel Zevenbergen; Serge Lemay

doi:10.1021/ac7016647

Nanofluidic redox cycling amplification for the selective detection of catechol

Bernhard Wolfrum, Marcel Zevenbergen, Serge Lemay^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

126 Citations (Scopus)

Abstract

We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.

Original language	English
Pages (from-to)	972-977
Number of pages	6
Journal	Analytical chemistry
Volume	80
Issue number	4
DOIs	https://doi.org/10.1021/ac7016647
Publication status	Published - 15 Feb 2008
Externally published	Yes

Access to Document

10.1021/ac7016647

Cite this

@article{234fdcf0aabf4cc58ec32a362626e563,

title = "Nanofluidic redox cycling amplification for the selective detection of catechol",

abstract = "We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.",

author = "Bernhard Wolfrum and Marcel Zevenbergen and Serge Lemay",

year = "2008",

month = feb,

day = "15",

doi = "10.1021/ac7016647",

language = "English",

volume = "80",

pages = "972--977",

journal = "Analytical chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Nanofluidic redox cycling amplification for the selective detection of catechol

AU - Wolfrum, Bernhard

AU - Zevenbergen, Marcel

AU - Lemay, Serge

PY - 2008/2/15

Y1 - 2008/2/15

N2 - We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.

AB - We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.

UR - http://www.scopus.com/inward/record.url?scp=39449105389&partnerID=8YFLogxK

U2 - 10.1021/ac7016647

DO - 10.1021/ac7016647

M3 - Article

C2 - 18193890

AN - SCOPUS:39449105389

SN - 0003-2700

VL - 80

SP - 972

EP - 977

JO - Analytical chemistry

JF - Analytical chemistry

IS - 4

ER -

Nanofluidic redox cycling amplification for the selective detection of catechol

Abstract

Access to Document

Other files and links

Fingerprint

Cite this