Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model

Alexey Klymov, Joost te Riet, Johannes G.E. Gardeniers, John A. Jansen, X. Frank Walboomers, Peter Mulder

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.
Original languageEnglish
Pages (from-to)2283-2290
JournalNanomedicine : nanotechnology, biology and medicine
Volume12
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • Nanotopography
  • Nanogrooves
  • Bone regeneration
  • Rat femoral condyle
  • Bone implants

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