Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model

Alexey Klymov, Joost te Riet, Johannes G.E. Gardeniers, John A. Jansen, X. Frank Walboomers, Peter Mulder

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.
Original languageEnglish
Pages (from-to)2283-2290
JournalNanomedicine : nanotechnology, biology and medicine
Volume12
Issue number8
DOIs
Publication statusPublished - 2016

Fingerprint

Bone Regeneration
Thigh
Topography
Rats
Bone
Bone and Bones
Epoxy Resins
Titanium
Epoxy resins
Surface roughness
Cancellous Bone

Keywords

  • Nanotopography
  • Nanogrooves
  • Bone regeneration
  • Rat femoral condyle
  • Bone implants

Cite this

Klymov, Alexey ; te Riet, Joost ; Gardeniers, Johannes G.E. ; Jansen, John A. ; Walboomers, X. Frank ; Mulder, Peter. / Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model. In: Nanomedicine : nanotechnology, biology and medicine. 2016 ; Vol. 12, No. 8. pp. 2283-2290.
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abstract = "Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.",
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Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model. / Klymov, Alexey; te Riet, Joost; Gardeniers, Johannes G.E.; Jansen, John A.; Walboomers, X. Frank; Mulder, Peter.

In: Nanomedicine : nanotechnology, biology and medicine, Vol. 12, No. 8, 2016, p. 2283-2290.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model

AU - Klymov, Alexey

AU - te Riet, Joost

AU - Gardeniers, Johannes G.E.

AU - Jansen, John A.

AU - Walboomers, X. Frank

AU - Mulder, Peter

PY - 2016

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N2 - Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.

AB - Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.

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KW - Rat femoral condyle

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