Abstract In the present study, a method was developed to reproduce two nanogrooved patterns (groove width/ridge width/depth: 150/150/50 nm and 200/800/70 nm) into cylindrical epoxy resin implants, which were subsequently coated with 20 nm of titanium. Also, implants with a conventional surface roughness (Rq = 1.6 μm) were produced. After cytocompatibility analysis of the produced surfaces, implants were installed into the femoral condyle of rats for 4 and 8 weeks. The histomorphometrical analysis of bone volume in a 100 μm wide zone close to the implant surface showed that only for the 200/800 grooves the amount of bone increased significantly between 4 and 8 weeks of implantation. In addition, at the late time point only implants with the 200/800 pattern revealed a significantly higher bone volume compared to the rough controls. In conclusion, the 200/800 grooved pattern can positively influence bone volume adjacent to the implant surface, and should be evaluated and optimized in further (pre-)clinical studies.
|Journal||Nanomedicine : nanotechnology, biology and medicine|
|Publication status||Published - 2016|
- Bone regeneration
- Rat femoral condyle
- Bone implants
Klymov, A., te Riet, J., Gardeniers, J. G. E., Jansen, J. A., Walboomers, X. F., & Mulder, P. (2016). Nanometer-grooved topography stimulates trabecular bone regeneration around a concave implant in a rat femoral medulla model. Nanomedicine : nanotechnology, biology and medicine, 12(8), 2283-2290. https://doi.org/10.1016/j.nano.2016.06.013