Nanoscale methods for single-molecule electrochemistry

Klaus Mathwig, Thijs J. Aartsma, Gerard W. Canters, Serge G. Lemay

Research output: Contribution to journalReview articleAcademicpeer-review

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The development of experiments capable of probing individual molecules has led to major breakthroughs in fields ranging from molecular electronics to biophysics, allowing direct tests of knowledge derived from macroscopic measurements and enabling new assays that probe population heterogeneities and internal molecular dynamics. Although still somewhat in their infancy, such methods are also being developed for probing molecular systems in solution using electrochemical transduction mechanisms. Here we outline the present status of this emerging field, concentrating in particular on optical methods, metal-molecule-metal junctions, and electrochemical nanofluidic devices. ©

Original languageEnglish
Pages (from-to)383-404
Number of pages22
JournalAnnual review of analytical chemistry
Publication statusPublished - Jun 2014


  • Electrochemical nanofluidics
  • Electron transfer
  • Fluorescence detection
  • Metal-molecule-metal junctions


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