Nanoscale organization of proteins via block copolymer lithography and non-covalent bioconjugation

I.C. Reynhout, G. Delaittre, H.C. Kim, R.J.M. Nolte, Jeroen Johannes Lambertus Maria Cornelissen

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Thin films of cylinder-forming biotinylated poly(ethylene glycol)-polystyrene (PEG-b-PS) block copolymers were studied as a means to produce protein patterns. The orientation of the PEG cylinders depended on the end group functionality as well as on the preparation conditions. In the case of perpendicular cylinders, immobilization of single streptavidin molecules could be achieved. This immobilization was controlled by varying the amount of biotin in the films by mixing with non-functional PEG-b-PS
Original languageEnglish
Pages (from-to)3026-3030
JournalJournal of materials chemistry. B: materials for biology and medicine
Volume1
Issue number24
DOIs
Publication statusPublished - 2013

Keywords

  • METIS-301673
  • IR-90145

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