Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

A. Nasajpour, S. Mandla, Sindhu Shree, Ebrahim Mostafavi, Roholah Sharifi, Akbar Khalilpour, Saghi Saghazadeh, Shabir Hassan, Michael J. Mitchell, J. Leijten, Xu Hou, Alireza Moshaverinia, Nasim Annabi, Rainer Adelung, Yogendra Kumar Mishra, Su Ryon Shin, Ali Tamayol, Ali Khademhosseini

Research output: Contribution to journalLetterAcademicpeer-review

35 Citations (Scopus)

Abstract

Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.
Original languageEnglish
Pages (from-to)6235-6240
Number of pages6
JournalNano letters
Volume17
Issue number10
DOIs
Publication statusPublished - 11 Oct 2017

Fingerprint

Fibrous membranes
spikes
Nanoparticles
membranes
nanoparticles
Zinc Oxide
Composite materials
Zinc oxide
stems
Scaffolds
zinc oxides
composite materials
eukaryotes
Fibers
fiber composites
Electrospinning
Scaffolds (biology)
Crystallization
activity (biology)
Bioactivity

Cite this

Nasajpour, A., Mandla, S., Shree, S., Mostafavi, E., Sharifi, R., Khalilpour, A., ... Khademhosseini, A. (2017). Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano letters, 17(10), 6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929
Nasajpour, A. ; Mandla, S. ; Shree, Sindhu ; Mostafavi, Ebrahim ; Sharifi, Roholah ; Khalilpour, Akbar ; Saghazadeh, Saghi ; Hassan, Shabir ; Mitchell, Michael J. ; Leijten, J. ; Hou, Xu ; Moshaverinia, Alireza ; Annabi, Nasim ; Adelung, Rainer ; Kumar Mishra, Yogendra ; Ryon Shin, Su ; Tamayol, Ali ; Khademhosseini, Ali. / Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. In: Nano letters. 2017 ; Vol. 17, No. 10. pp. 6235-6240.
@article{8df17471090d452aba2b5cb2ed694592,
title = "Nanostructured Fibrous Membranes with Rose Spike-Like Architecture",
abstract = "Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.",
author = "A. Nasajpour and S. Mandla and Sindhu Shree and Ebrahim Mostafavi and Roholah Sharifi and Akbar Khalilpour and Saghi Saghazadeh and Shabir Hassan and Mitchell, {Michael J.} and J. Leijten and Xu Hou and Alireza Moshaverinia and Nasim Annabi and Rainer Adelung and {Kumar Mishra}, Yogendra and {Ryon Shin}, Su and Ali Tamayol and Ali Khademhosseini",
year = "2017",
month = "10",
day = "11",
doi = "10.1021/acs.nanolett.7b02929",
language = "English",
volume = "17",
pages = "6235--6240",
journal = "Nano letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "10",

}

Nasajpour, A, Mandla, S, Shree, S, Mostafavi, E, Sharifi, R, Khalilpour, A, Saghazadeh, S, Hassan, S, Mitchell, MJ, Leijten, J, Hou, X, Moshaverinia, A, Annabi, N, Adelung, R, Kumar Mishra, Y, Ryon Shin, S, Tamayol, A & Khademhosseini, A 2017, 'Nanostructured Fibrous Membranes with Rose Spike-Like Architecture' Nano letters, vol. 17, no. 10, pp. 6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929

Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. / Nasajpour, A.; Mandla, S.; Shree, Sindhu; Mostafavi, Ebrahim; Sharifi, Roholah; Khalilpour, Akbar; Saghazadeh, Saghi; Hassan, Shabir; Mitchell, Michael J.; Leijten, J.; Hou, Xu; Moshaverinia, Alireza; Annabi, Nasim; Adelung, Rainer; Kumar Mishra, Yogendra; Ryon Shin, Su; Tamayol, Ali; Khademhosseini, Ali.

In: Nano letters, Vol. 17, No. 10, 11.10.2017, p. 6235-6240.

Research output: Contribution to journalLetterAcademicpeer-review

TY - JOUR

T1 - Nanostructured Fibrous Membranes with Rose Spike-Like Architecture

AU - Nasajpour, A.

AU - Mandla, S.

AU - Shree, Sindhu

AU - Mostafavi, Ebrahim

AU - Sharifi, Roholah

AU - Khalilpour, Akbar

AU - Saghazadeh, Saghi

AU - Hassan, Shabir

AU - Mitchell, Michael J.

AU - Leijten, J.

AU - Hou, Xu

AU - Moshaverinia, Alireza

AU - Annabi, Nasim

AU - Adelung, Rainer

AU - Kumar Mishra, Yogendra

AU - Ryon Shin, Su

AU - Tamayol, Ali

AU - Khademhosseini, Ali

PY - 2017/10/11

Y1 - 2017/10/11

N2 - Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

AB - Nanoparticles have been used for engineering composite materials to improve the intrinsic properties and/or add functionalities to pristine polymers. The majority of the studies have focused on the incorporation of spherical nanoparticles within the composite fibers. Herein, we incorporate anisotropic branched-shaped zinc oxide (ZnO) nanoparticles into fibrous scaffolds fabricated by electrospinning. The addition of the branched particles resulted in their protrusion from fibers, mimicking the architecture of a rose stem. We demonstrated that the encapsulation of different-shape particles significantly influences the physicochemical and biological activities of the resultant composite scaffolds. In particular, the branched nanoparticles induced heterogeneous crystallization of the polymeric matrix and enhance the ultimate mechanical strain and strength. Moreover, the three-dimensional (3D) nature of the branched ZnO nanoparticles enhanced adhesion properties of the composite scaffolds to the tissues. In addition, the rose stem-like constructs offered excellent antibacterial activity, while supporting the growth of eukaryote cells.

U2 - 10.1021/acs.nanolett.7b02929

DO - 10.1021/acs.nanolett.7b02929

M3 - Letter

VL - 17

SP - 6235

EP - 6240

JO - Nano letters

JF - Nano letters

SN - 1530-6984

IS - 10

ER -

Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A et al. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano letters. 2017 Oct 11;17(10):6235-6240. https://doi.org/10.1021/acs.nanolett.7b02929