Nanotherapeutics and Nanotheragnostics for Cancers: Properties, Pharmacokinetics, Biopharmaceutics, and Biosafety

Margreet Morsink, Lucia Parente, Fernanda Silva, Alexandra Abrantes, Ana Ramos, Inês Primo, Niels Willemen, Elena Sanchez-Lopez, Patricia Severino, Eliana B. Souto*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)


With the increasing worldwide rate of chronic diseases, such as cancer, the development of novel techniques to improve the efficacy of therapeutic agents is highly demanded. Nanoparticles are especially well suited to encapsulate drugs and other therapeutic agents, bringing additional advantages, such as less frequent dosage requirements, reduced side effects due to specific targeting, and therefore increased patient compliance. However, with the increasing use of nanoparticles and their recent launch on the pharmaceutical market, it is important to achieve high-quality control of these advanced systems. In this review, we discuss the properties of different nanoparticles, the pharmacokinetics, the biosafety issues of concern, and conclude with novel nanotherapeutics and nanotheragnostics for cancer drug delivery.

Original languageEnglish
Pages (from-to)104-115
Number of pages12
JournalCurrent Pharmaceutical Design
Issue number2
Early online date3 Aug 2021
Publication statusPublished - 1 Jan 2022
Externally publishedYes


  • Advanced drug delivery
  • Cancer drug delivery
  • Cancer nanotheragnostics
  • Drug nanoparticles
  • Nanomedicine
  • Nanosafety
  • Nanotheragnostics
  • Nanotherapeutics
  • Pharmacokinetics


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