Network activity patterns in the subthalamic nucleus of the rat

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    In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.
    Original languageUndefined
    Title of host publicationConference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays
    Place of PublicationReutlingen, Germany
    PublisherFischBach Druck GmbH
    Number of pages2
    ISBN (Print)978-3-938345-08-5
    Publication statusPublished - 29 Jun 2010
    Event7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 - Reutlingen, Germany
    Duration: 29 Jun 20102 Jul 2010
    Conference number: 7

    Publication series

    PublisherFischBach Druck GmbH


    Conference7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010
    Abbreviated titleMEA


    • IR-72298
    • EWI-18105
    • METIS-275600

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