Network activity patterns in the subthalamic nucleus of the rat

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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    Abstract

    In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.
    Original languageUndefined
    Title of host publicationConference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays
    Place of PublicationReutlingen, Germany
    PublisherFischBach Druck GmbH
    Pages49-50
    Number of pages2
    ISBN (Print)978-3-938345-08-5
    Publication statusPublished - 29 Jun 2010
    Event7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 - Reutlingen, Germany
    Duration: 29 Jun 20102 Jul 2010
    Conference number: 7

    Publication series

    Name
    PublisherFischBach Druck GmbH

    Conference

    Conference7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010
    Abbreviated titleMEA
    CountryGermany
    CityReutlingen
    Period29/06/102/07/10

    Keywords

    • IR-72298
    • EWI-18105
    • METIS-275600

    Cite this

    Stegenga, J., van Wezel, R. J. A., & Heida, T. (2010). Network activity patterns in the subthalamic nucleus of the rat. In Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays (pp. 49-50). Reutlingen, Germany: FischBach Druck GmbH.
    Stegenga, J. ; van Wezel, Richard Jack Anton ; Heida, Tjitske. / Network activity patterns in the subthalamic nucleus of the rat. Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. Reutlingen, Germany : FischBach Druck GmbH, 2010. pp. 49-50
    @inproceedings{e424f79036054ec5aeb65ea5b6aaa6e8,
    title = "Network activity patterns in the subthalamic nucleus of the rat",
    abstract = "In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.",
    keywords = "IR-72298, EWI-18105, METIS-275600",
    author = "J. Stegenga and {van Wezel}, {Richard Jack Anton} and Tjitske Heida",
    year = "2010",
    month = "6",
    day = "29",
    language = "Undefined",
    isbn = "978-3-938345-08-5",
    publisher = "FischBach Druck GmbH",
    pages = "49--50",
    booktitle = "Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays",

    }

    Stegenga, J, van Wezel, RJA & Heida, T 2010, Network activity patterns in the subthalamic nucleus of the rat. in Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. FischBach Druck GmbH, Reutlingen, Germany, pp. 49-50, 7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010, Reutlingen, Germany, 29/06/10.

    Network activity patterns in the subthalamic nucleus of the rat. / Stegenga, J.; van Wezel, Richard Jack Anton; Heida, Tjitske.

    Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. Reutlingen, Germany : FischBach Druck GmbH, 2010. p. 49-50.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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    N2 - In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.

    AB - In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.

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    Stegenga J, van Wezel RJA, Heida T. Network activity patterns in the subthalamic nucleus of the rat. In Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. Reutlingen, Germany: FischBach Druck GmbH. 2010. p. 49-50