Network activity patterns in the subthalamic nucleus of the rat

J. Stegenga; Richard Jack Anton van Wezel; Tjitske Heida

Network activity patterns in the subthalamic nucleus of the rat

J. Stegenga, Richard Jack Anton van Wezel, Tjitske Heida

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.

Original language	Undefined
Title of host publication	Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays
Place of Publication	Reutlingen, Germany
Publisher	FischBach Druck GmbH
Pages	49-50
Number of pages	2
ISBN (Print)	978-3-938345-08-5
Publication status	Published - 29 Jun 2010
Event	7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 - Reutlingen, Germany Duration: 29 Jun 2010 → 2 Jul 2010 Conference number: 7

Publication series

Name
Publisher	FischBach Druck GmbH

Conference

Conference	7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010
Abbreviated title	MEA
Country/Territory	Germany
City	Reutlingen
Period	29/06/10 → 2/07/10

Keywords

IR-72298
EWI-18105
METIS-275600

Access to Document

MEAmeeting2010abstract

Cite this

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title = "Network activity patterns in the subthalamic nucleus of the rat",

abstract = "In Parkinson{\textquoteright}s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson{\textquoteright}s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.",

keywords = "IR-72298, EWI-18105, METIS-275600",

author = "J. Stegenga and {van Wezel}, {Richard Jack Anton} and Tjitske Heida",

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booktitle = "Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays",

note = "7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010 ; Conference date: 29-06-2010 Through 02-07-2010",

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Stegenga, J, van Wezel, RJA & Heida, T 2010, Network activity patterns in the subthalamic nucleus of the rat. in Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. FischBach Druck GmbH, Reutlingen, Germany, pp. 49-50, 7th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2010, Reutlingen, Germany, 29/06/10.

Network activity patterns in the subthalamic nucleus of the rat. / Stegenga, J.; van Wezel, Richard Jack Anton ; Heida, Tjitske.
Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays. Reutlingen, Germany: FischBach Druck GmbH, 2010. p. 49-50.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Network activity patterns in the subthalamic nucleus of the rat

AU - Stegenga, J.

AU - van Wezel, Richard Jack Anton

AU - Heida, Tjitske

N1 - Conference code: 7

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N2 - In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.

AB - In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others involved in motor tasks), we are now measuring neuronal activity in brain slices containing STN using 3D-MEAs. 3D-MEAs offer the possibility to measure a large number of sites simultaneously in slices which retain in-vivo topography and connectivity. This approach is not yet used within Parkinson’s Disease research and may answer crucial questions about the (patho-) physiology of the STN and surrounding network.

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BT - Conference proceedings of the 7th International Meeting on Substrate-Integrated Microelectrode Arrays

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