Neural growth into a microchannel network: towards a regenerative neural interface

P.A. Wieringa; Remy Wiertz; Jakob le Feber; Wim Rutten

doi:10.1109/NER.2009.5109232

Neural growth into a microchannel network: towards a regenerative neural interface

P.A. Wieringa, Remy Wiertz, Jakob le Feber, Wim Rutten

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

3 Citations (Scopus)

207 Downloads (Pure)

Abstract

We propose and validated a design for a highly selective 'endcap' regenerative neural interface towards a neuroprosthesis. In vitro studies using rat cortical neurons determine if a branching microchannel structure can counter fasciculated growth and cause neurites to separte from one another, allowing for greater selective contact. Initial studies find that narrower branching microchannels achieve improved neurite separation. Electical stimulation of neurites within michrochannels is possible, as is recording of neurite action potentials with the microchannels acting as electrical singal amplifiers.

Original language	Undefined
Title of host publication	Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering
Place of Publication	Piscataway
Publisher	IEEE
Pages	51-55
Number of pages	5
ISBN (Print)	978-1-4244-2073-5
DOIs	https://doi.org/10.1109/NER.2009.5109232
Publication status	Published - 29 Apr 2009
Event	4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 - Antalya, Turkey Duration: 29 Apr 2009 → 2 May 2009 Conference number: 4

Publication series

Name
Publisher	IEEE-EMBS

Conference

Conference	4th International IEEE/EMBS Conference on Neural Engineering, NER 2009
Abbreviated title	NER
Country/Territory	Turkey
City	Antalya
Period	29/04/09 → 2/05/09

Keywords

EWI-15361
BSS-Neurotechnology and cellular engineering
METIS-265206
IR-65493
neural growth michrochannel network neural interface

Access to Document

10.1109/NER.2009.5109232

Cite this

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title = "Neural growth into a microchannel network: towards a regenerative neural interface",

abstract = "We propose and validated a design for a highly selective 'endcap' regenerative neural interface towards a neuroprosthesis. In vitro studies using rat cortical neurons determine if a branching microchannel structure can counter fasciculated growth and cause neurites to separte from one another, allowing for greater selective contact. Initial studies find that narrower branching microchannels achieve improved neurite separation. Electical stimulation of neurites within michrochannels is possible, as is recording of neurite action potentials with the microchannels acting as electrical singal amplifiers.",

keywords = "EWI-15361, BSS-Neurotechnology and cellular engineering, METIS-265206, IR-65493, neural growth michrochannel network neural interface",

author = "P.A. Wieringa and Remy Wiertz and {le Feber}, Jakob and Wim Rutten",

year = "2009",

month = apr,

day = "29",

doi = "10.1109/NER.2009.5109232",

language = "Undefined",

isbn = "978-1-4244-2073-5",

publisher = "IEEE",

pages = "51--55",

booktitle = "Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering",

address = "United States",

note = "4th International IEEE/EMBS Conference on Neural Engineering, NER 2009 ; Conference date: 29-04-2009 Through 02-05-2009",

}

Wieringa, PA, Wiertz, R, le Feber, J & Rutten, W 2009, Neural growth into a microchannel network: towards a regenerative neural interface. in Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering. IEEE, Piscataway, pp. 51-55, 4th International IEEE/EMBS Conference on Neural Engineering, NER 2009, Antalya, Turkey, 29/04/09. https://doi.org/10.1109/NER.2009.5109232

Neural growth into a microchannel network: towards a regenerative neural interface. / Wieringa, P.A.; Wiertz, Remy; le Feber, Jakob et al.
Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering. Piscataway: IEEE, 2009. p. 51-55.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Neural growth into a microchannel network: towards a regenerative neural interface

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AU - Wiertz, Remy

AU - le Feber, Jakob

AU - Rutten, Wim

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N2 - We propose and validated a design for a highly selective 'endcap' regenerative neural interface towards a neuroprosthesis. In vitro studies using rat cortical neurons determine if a branching microchannel structure can counter fasciculated growth and cause neurites to separte from one another, allowing for greater selective contact. Initial studies find that narrower branching microchannels achieve improved neurite separation. Electical stimulation of neurites within michrochannels is possible, as is recording of neurite action potentials with the microchannels acting as electrical singal amplifiers.

AB - We propose and validated a design for a highly selective 'endcap' regenerative neural interface towards a neuroprosthesis. In vitro studies using rat cortical neurons determine if a branching microchannel structure can counter fasciculated growth and cause neurites to separte from one another, allowing for greater selective contact. Initial studies find that narrower branching microchannels achieve improved neurite separation. Electical stimulation of neurites within michrochannels is possible, as is recording of neurite action potentials with the microchannels acting as electrical singal amplifiers.

KW - EWI-15361

KW - BSS-Neurotechnology and cellular engineering

KW - METIS-265206

KW - IR-65493

KW - neural growth michrochannel network neural interface

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DO - 10.1109/NER.2009.5109232

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BT - Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering

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T2 - 4th International IEEE/EMBS Conference on Neural Engineering, NER 2009

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