Neuronal adhesion and growth on polyethylenimine tracks microprinted on polyethyleneoxide-polypropyleneoxide coated surfaces

T.G. Ruardij, M.A.F. van den Boogaart, Wim Rutten

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    Abstract

    Adsorbed layers of polyediylenoxide-polypropylenoxide (PEO-PPO) blockcopolymers were tested as neurophobic background coatings in neuronal patterning studies over a time period of 30 days. Microprinted tracks of polyethylenimine (PEI) were used as the neuron-adhesive part of the pattern. Results showed that PEO-PPO surfactants F108 and F127 (Synperonics, ICI) significantly reduced the growth of neuronal tissue when adsorbed on Polyimide and Fluorocarbon surfaces up till 8 days. Also survival of neuronal tissue was not negatively affected by the PEO-PPO. Viability of the cultures was assessed after 30 days and showed viability factors above 0.9 (scale 0 to 1).
    Original languageEnglish
    Title of host publicationSecond joint IEEE-EMBS/BMES Conference 2002
    PublisherIEEE
    Pages2121-2122
    Number of pages2
    ISBN (Print)0-7803-7613-7, 0-7803-7612-9
    DOIs
    Publication statusPublished - 23 Oct 2002
    EventSecond Joint EMBS/BMES Conference 2002 - Houston, United States
    Duration: 23 Oct 200226 Oct 2002
    Conference number: 2

    Conference

    ConferenceSecond Joint EMBS/BMES Conference 2002
    CountryUnited States
    CityHouston
    Period23/10/0226/10/02

    Keywords

    • IR-43912
    • METIS-207689

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