Neuronaltoll-like receptors and neuro-immunity in parkinson's disease, Alzheimer's disease and stroke

Carmen D. Rietdijk, Richard Jack Anton van Wezel, Johan Garssen, Aletta D. Kraneveld

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    Abstract

    Toll-like receptors (TLRs) are part of the innate immune system and can initiate an immune response upon exposure to harmful microorganisms. Neuronal TLRs are considered to be part of an established framework of interactions between the immune system and the nervous system, the major sensing systems in mammals. TLRs in the nervous system and neuronal TLRs are suspected to be important during inflammation and neurodegenerative diseases. The aim of this review is to offer an overview of the current knowledge about TLRs in neurodegenerative pathologies, with a focus on Parkinson’s disease. More research focusing on the role of TLRs in health and disease of the nervous system is needed and remains to be explored.
    Original languageUndefined
    Pages (from-to)27-37
    Number of pages11
    JournalNeuroimmunology and neuroinflammation
    Volume3
    Issue number2
    DOIs
    Publication statusPublished - 15 Feb 2016

    Keywords

    • infection
    • toll-like receptor
    • EWI-27375
    • Alzheimer’s disease
    • IR-104299
    • neurodegeneration
    • neurodevelopment
    • Parkinson’s disease
    • Stroke
    • Neuron

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