Neurophysiology State Dynamics Underlying Acute Neurologic Recovery After Cardiac Arrest

Edilberto Amorim*, Wei Long Zheng, Jin Jing, Mohammad M. Ghassemi, Jong Woo Lee, Ona Wu, Susan T. Herman, Trudy Pang, Adithya Sivaraju, Nicolas Gaspard, Lawrence Hirsch, Barry J. Ruijter, Marleen C. Tjepkema-Cloostermans, Jeannette Hofmeijer, Michel J.A.M. van Putten, M. Brandon Westover

*Corresponding author for this work

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Abstract

BACKGROUND AND OBJECTIVES: Epileptiform activity and burst suppression are neurophysiology signatures reflective of severe brain injury after cardiac arrest. We aimed to delineate the evolution of coma neurophysiology feature ensembles associated with recovery from coma after cardiac arrest. METHODS: Adults in acute coma after cardiac arrest were included in a retrospective database involving 7 hospitals. The combination of 3 quantitative EEG features (burst suppression ratio [BSup], spike frequency [SpF], and Shannon entropy [En]) was used to define 5 distinct neurophysiology states: epileptiform high entropy (EHE: SpF ≥4 per minute and En ≥5); epileptiform low entropy (ELE: SpF ≥4 per minute and <5 En); nonepileptiform high entropy (NEHE: SpF <4 per minute and ≥5 En); nonepileptiform low entropy (NELE: SpF <4 per minute and <5 En), and burst suppression (BSup ≥50% and SpF <4 per minute). State transitions were measured at consecutive 6-hour blocks between 6 and 84 hours after return of spontaneous circulation. Good neurologic outcome was defined as best cerebral performance category 1-2 at 3-6 months. RESULTS: One thousand thirty-eight individuals were included (50,224 hours of EEG), and 373 (36%) had good outcome. Individuals with EHE state had a 29% rate of good outcome, while those with ELE had 11%. Transitions out of an EHE or BSup state to an NEHE state were associated with good outcome (45% and 20%, respectively). No individuals with ELE state lasting >15 hours had good recovery. DISCUSSION: Transition to high entropy states is associated with an increased likelihood of good outcome despite preceding epileptiform or burst suppression states. High entropy may reflect mechanisms of resilience to hypoxic-ischemic brain injury.

Original languageEnglish
Pages (from-to)e940-e952
JournalNeurology
Volume101
Issue number9
DOIs
Publication statusPublished - 29 Aug 2023

Keywords

  • 2023 OA procedure

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