TY - JOUR
T1 - New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection
AU - Guijt, Rosanne M.
AU - Baltussen, Erik
AU - van der Steen, Gert
AU - Schasfoort, Richard B.M.
AU - Schlautmann, Stefan
AU - Billiet, Hugo A.H.
AU - Frank, Johannes
AU - van Dedem, Gijs W.K.
AU - van den Berg, Albert
PY - 2001
Y1 - 2001
N2 - In practice, microfluidic systems are based on the principles of capillary electrophoresis (CE), for a large part due to the simplicity of electroosmotic pumping. In this contribution, a universal conductivity detector is presented that allows detection of charged species down to the µM level. Additionally, powderblasting is presented as a novel technique for direct etching of microfluidic networks. This method allows creation of features down to 50 µm with a total processing time (design to device) of less than one day. The performance of powderblasted devices with integrated conductivity detection is illustrated by the separation of lithium, sodium, and potassium ions and that of fumaric, malic, and citric acid.
AB - In practice, microfluidic systems are based on the principles of capillary electrophoresis (CE), for a large part due to the simplicity of electroosmotic pumping. In this contribution, a universal conductivity detector is presented that allows detection of charged species down to the µM level. Additionally, powderblasting is presented as a novel technique for direct etching of microfluidic networks. This method allows creation of features down to 50 µm with a total processing time (design to device) of less than one day. The performance of powderblasted devices with integrated conductivity detection is illustrated by the separation of lithium, sodium, and potassium ions and that of fumaric, malic, and citric acid.
KW - Micro machining
KW - Capillary electrophoresis
KW - Conductivity detection
KW - Micro-total analysis systems
U2 - 10.1002/1522-2683(200101)22:2<235::AID-ELPS235>3.0.CO;2-O
DO - 10.1002/1522-2683(200101)22:2<235::AID-ELPS235>3.0.CO;2-O
M3 - Article
SN - 0173-0835
VL - 22
SP - 235
EP - 241
JO - Electrophoresis
JF - Electrophoresis
IS - 2
ER -