New approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection

Rosanne M. Guijt, Erik Baltussen, Gert van der Steen, Richardus B.M. Schasfoort, Stefan Schlautmann, Hugo A.H. Billiet, Johannes Frank, Gijs W.K. van Dedem, Albert van den Berg

Research output: Contribution to journalArticleAcademic

110 Citations (Scopus)

Abstract

In practice, microfluidic systems are based on the principles of capillary electrophoresis (CE), for a large part due to the simplicity of electroosmotic pumping. In this contribution, a universal conductivity detector is presented that allows detection of charged species down to the µM level. Additionally, powderblasting is presented as a novel technique for direct etching of microfluidic networks. This method allows creation of features down to 50 µm with a total processing time (design to device) of less than one day. The performance of powderblasted devices with integrated conductivity detection is illustrated by the separation of lithium, sodium, and potassium ions and that of fumaric, malic, and citric acid.
Original languageUndefined
Pages (from-to)235-241
JournalElectrophoresis
Volume22
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Micro machining
  • Capillary electrophoresis
  • Conductivity detection
  • Micro-total analysis systems
  • IR-71822

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