New diagnostic and treatment strategies in renal artery stenosis: A promising pursuit or disappointment foretold?

L. van de Velde, D. Collard, W. Spiering, P.M. van Brussel, J. Versmissen, T. Wierema, M.W. de Haan, IJ.A.J. Zijlstra, A.A. Kroon, L. Vogt, P.W. de Leeuw, D. van Twist, B.J.H. van den Born*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Clinical management of renal artery stenosis has seen a major shift, after randomised clinical trials have shown no group benefit of endovascular intervention relative to optimal medical control. However, the inclusion criteria of these trials have been criticised for focusing on a subset of patients with atherosclerotic renal artery stenosis where intervention was unlikely to be beneficial. Moreover, new imaging and computational techniques have become available, which have the potential to improve identification of patients that will respond to interventional treatment. This review addresses the challenges associated with clinical decision making in patients with renal artery stenosis. Opportunities for novel diagnostic techniques to improve patient selection are discussed, along with ongoing Dutch studies and network initiatives that investigate these strategies.

Original languageEnglish
Pages (from-to)232-238
Number of pages7
JournalNetherlands journal of medicine
Volume78
Issue number5
Publication statusPublished - Sep 2020

Keywords

  • Computational fluid dynamics
  • Fibromuscular dysplasia
  • Functional measurements
  • Renal artery stenosis
  • Renovascular disease
  • Secondary hypertension

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