New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results

Alexander Serov, Sjoerd Oosterbaan, J. Nieland, Janharm Nieland, H. van Kranenburg, R. Verboom, Herman H.P.T. Bekman, F.F.M. de Mul, Wiendelt Steenbergen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)

Abstract

Integrated probes have been developed containing the essential optoelectronic components necessary for monitoring tissue perfusion using the laser Doppler principle. The device contains a VCSEL for illumination, and a chip with photodetectors, amplifiers for signal enhancement, and digital circuitry for external probe control. VCSEL and detector chip are mounted on a common ceramic platform. A Peltier element may be included for temperature stabilisation, or thermal cycling for physiological purposes. Two special chips have been developed: one containing an array of five detectors, at various distances from the laser, which will allow for some degree of depth discrimination, and a single detector chip. In this paper the probe designs are presented and some results of in vivo measurements are shown.
Original languageEnglish
Title of host publicationSPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV
EditorsT. Vo-Dinh, D.A. Benaron, W.S. Grundfest
PublisherSPIE
Pages165-172
Number of pages8
ISBN (Print)1605-7422
DOIs
Publication statusPublished - 20 Jan 2002

Publication series

NameProceedings of SPIE
PublisherSPIE
Number7
Volume3

Fingerprint

chips
probes
lasers
detectors
photometers
discrimination
platforms
amplifiers
stabilization
illumination
ceramics
cycles
augmentation
temperature

Keywords

  • METIS-205965
  • IR-96437

Cite this

Serov, A., Oosterbaan, S., Nieland, J., Nieland, J., van Kranenburg, H., Verboom, R., ... Steenbergen, W. (2002). New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. In T. Vo-Dinh, D. A. Benaron, & W. S. Grundfest (Eds.), SPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV (pp. 165-172). (Proceedings of SPIE; Vol. 3, No. 7). SPIE. https://doi.org/10.1117/12.466644
Serov, Alexander ; Oosterbaan, Sjoerd ; Nieland, J. ; Nieland, Janharm ; van Kranenburg, H. ; Verboom, R. ; Bekman, Herman H.P.T. ; de Mul, F.F.M. ; Steenbergen, Wiendelt. / New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. SPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV. editor / T. Vo-Dinh ; D.A. Benaron ; W.S. Grundfest. SPIE, 2002. pp. 165-172 (Proceedings of SPIE; 7).
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abstract = "Integrated probes have been developed containing the essential optoelectronic components necessary for monitoring tissue perfusion using the laser Doppler principle. The device contains a VCSEL for illumination, and a chip with photodetectors, amplifiers for signal enhancement, and digital circuitry for external probe control. VCSEL and detector chip are mounted on a common ceramic platform. A Peltier element may be included for temperature stabilisation, or thermal cycling for physiological purposes. Two special chips have been developed: one containing an array of five detectors, at various distances from the laser, which will allow for some degree of depth discrimination, and a single detector chip. In this paper the probe designs are presented and some results of in vivo measurements are shown.",
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Serov, A, Oosterbaan, S, Nieland, J, Nieland, J, van Kranenburg, H, Verboom, R, Bekman, HHPT, de Mul, FFM & Steenbergen, W 2002, New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. in T Vo-Dinh, DA Benaron & WS Grundfest (eds), SPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV. Proceedings of SPIE, no. 7, vol. 3, SPIE, pp. 165-172. https://doi.org/10.1117/12.466644

New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. / Serov, Alexander; Oosterbaan, Sjoerd; Nieland, J.; Nieland, Janharm; van Kranenburg, H.; Verboom, R.; Bekman, Herman H.P.T.; de Mul, F.F.M.; Steenbergen, Wiendelt.

SPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV. ed. / T. Vo-Dinh; D.A. Benaron; W.S. Grundfest. SPIE, 2002. p. 165-172 (Proceedings of SPIE; Vol. 3, No. 7).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Serov A, Oosterbaan S, Nieland J, Nieland J, van Kranenburg H, Verboom R et al. New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. In Vo-Dinh T, Benaron DA, Grundfest WS, editors, SPIE: Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV. SPIE. 2002. p. 165-172. (Proceedings of SPIE; 7). https://doi.org/10.1117/12.466644