New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results

A. Serov, Sj. Oosterbaan, J. Nieland, H. van Kranenburg, R. Verboom, H.H.T.Ph. Bekman, F.F.M. de Mul, W. Steenbergen

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Abstract

Integrated probes have been developed containing the essential optoelectronic components necessary for monitoring tissue perfusion using the laser Doppler principle. The device contains a VCSEL for illumination, and a chip with photodetectors, amplifiers for signal enhancement, and digital circuitry for external probe control. VCSEL and detector chip are mounted on a common ceramic platform. A Peltier element may be included for temperature stabilisation, or thermal cycling for physiological purposes. Two special chips have been developed: one containing an array of five detectors, at various distances from the laser, which will allow for some degree of depth discrimination, and a single detector chip. In this paper the probe designs are presented and some results of in vivo measurements are shown.
Original languageEnglish
Title of host publicationBiomedical Diagnostic, Guidance, and Surgical-Assist Systems IV
EditorsT. Vo-Dinh, D.A. Benaron, W.S. Grundfest
PublisherSPIE
Pages165-172
Number of pages8
DOIs
Publication statusPublished - 20 Jan 2002

Publication series

NameProceedings of SPIE
PublisherSPIE
Number7
Volume3
ISSN (Print)1605-7422

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Serov, A., Oosterbaan, S., Nieland, J., van Kranenburg, H., Verboom, R., Bekman, H. H. T. P., ... Steenbergen, W. (2002). New generation of integrated probes for laser Doppler perfusion monitoring: construction and in vivo results. In T. Vo-Dinh, D. A. Benaron, & W. S. Grundfest (Eds.), Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV (pp. 165-172). (Proceedings of SPIE; Vol. 3, No. 7). SPIE. https://doi.org/10.1117/12.466644