NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

Tim J.M. Welting, Marcel Karperien, Janine Nicole Post (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

10 Downloads (Pure)

Abstract

The cellular fraction of cartilage is mainly composed of one single cell type, the chondrocyte, which secretes, shapes and maintains the cartilaginous matrix that functions, in the case of epiphyseal cartilage, as the template for bone elongation. The biomechanical properties of cartilage are dependent mainly on the composition, as well as the macromolecular integrity of its matrix contributing to the functional and phenotypic differences between cartilage subtypes (1). For example, articular cartilage (AC) is a highly resilient tissue that allows low-friction joint articulation. In contrast, growth plate (GP) cartilage is populated by highly proliferative chondrocytes that undergo hypertrophic differentiation in an angiogenesis-promoting spatiotemporal manner, serving as a mold for longitudinal bone growth. As such, an in sharp contrast to AC, GP cartilage is a transient tissue and is replaced by bone in a process known as endochondral ossification (2).
Original languageEnglish
Number of pages5
JournalBiotarget
Volume2
Issue number11
DOIs
Publication statusPublished - 17 Jul 2017

Fingerprint

Chondrocytes
Cartilage
Growth Plate
Articular Cartilage
Bone and Bones
Friction
Bone Development
Osteogenesis
Fungi
Joints

Cite this

@article{ce0c8affb9af402e80010c1224d1bf07,
title = "NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes",
abstract = "The cellular fraction of cartilage is mainly composed of one single cell type, the chondrocyte, which secretes, shapes and maintains the cartilaginous matrix that functions, in the case of epiphyseal cartilage, as the template for bone elongation. The biomechanical properties of cartilage are dependent mainly on the composition, as well as the macromolecular integrity of its matrix contributing to the functional and phenotypic differences between cartilage subtypes (1). For example, articular cartilage (AC) is a highly resilient tissue that allows low-friction joint articulation. In contrast, growth plate (GP) cartilage is populated by highly proliferative chondrocytes that undergo hypertrophic differentiation in an angiogenesis-promoting spatiotemporal manner, serving as a mold for longitudinal bone growth. As such, an in sharp contrast to AC, GP cartilage is a transient tissue and is replaced by bone in a process known as endochondral ossification (2).",
author = "Welting, {Tim J.M.} and Marcel Karperien and Post, {Janine Nicole}",
year = "2017",
month = "7",
day = "17",
doi = "10.21037/biotarget.2018.07.01",
language = "English",
volume = "2",
journal = "Biotarget",
issn = "2522-669X",
publisher = "AME Publishing Company",
number = "11",

}

NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes. / Welting, Tim J.M.; Karperien, Marcel; Post, Janine Nicole (Corresponding Author).

In: Biotarget, Vol. 2, No. 11, 17.07.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes

AU - Welting, Tim J.M.

AU - Karperien, Marcel

AU - Post, Janine Nicole

PY - 2017/7/17

Y1 - 2017/7/17

N2 - The cellular fraction of cartilage is mainly composed of one single cell type, the chondrocyte, which secretes, shapes and maintains the cartilaginous matrix that functions, in the case of epiphyseal cartilage, as the template for bone elongation. The biomechanical properties of cartilage are dependent mainly on the composition, as well as the macromolecular integrity of its matrix contributing to the functional and phenotypic differences between cartilage subtypes (1). For example, articular cartilage (AC) is a highly resilient tissue that allows low-friction joint articulation. In contrast, growth plate (GP) cartilage is populated by highly proliferative chondrocytes that undergo hypertrophic differentiation in an angiogenesis-promoting spatiotemporal manner, serving as a mold for longitudinal bone growth. As such, an in sharp contrast to AC, GP cartilage is a transient tissue and is replaced by bone in a process known as endochondral ossification (2).

AB - The cellular fraction of cartilage is mainly composed of one single cell type, the chondrocyte, which secretes, shapes and maintains the cartilaginous matrix that functions, in the case of epiphyseal cartilage, as the template for bone elongation. The biomechanical properties of cartilage are dependent mainly on the composition, as well as the macromolecular integrity of its matrix contributing to the functional and phenotypic differences between cartilage subtypes (1). For example, articular cartilage (AC) is a highly resilient tissue that allows low-friction joint articulation. In contrast, growth plate (GP) cartilage is populated by highly proliferative chondrocytes that undergo hypertrophic differentiation in an angiogenesis-promoting spatiotemporal manner, serving as a mold for longitudinal bone growth. As such, an in sharp contrast to AC, GP cartilage is a transient tissue and is replaced by bone in a process known as endochondral ossification (2).

U2 - 10.21037/biotarget.2018.07.01

DO - 10.21037/biotarget.2018.07.01

M3 - Article

VL - 2

JO - Biotarget

JF - Biotarget

SN - 2522-669X

IS - 11

ER -