Non-contact spectroscopic determination of large blood volume fractions in turbid media

R.H. Bremmer; S.C. Kanick; N. Laan; A. Amelink; Ton van Leeuwen; M.C.G. Aalders

doi:10.1364/BOE.2.000396

Non-contact spectroscopic determination of large blood volume fractions in turbid media

R.H. Bremmer, S.C. Kanick, N. Laan, A. Amelink, Ton van Leeuwen, M.C.G. Aalders

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μa and μs′ on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms.

Original language	English
Pages (from-to)	396-407
Journal	Biomedical optics express
Volume	2
Issue number	2
DOIs	https://doi.org/10.1364/BOE.2.000396
Publication status	Published - 2011

Keywords

METIS-293100
IR-83155

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10.1364/BOE.2.000396

Bremmer11non

Cite this

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title = "Non-contact spectroscopic determination of large blood volume fractions in turbid media",

abstract = "We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μa and μs′ on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms.",

keywords = "METIS-293100, IR-83155",

author = "R.H. Bremmer and S.C. Kanick and N. Laan and A. Amelink and {van Leeuwen}, Ton and M.C.G. Aalders",

year = "2011",

doi = "10.1364/BOE.2.000396",

language = "English",

volume = "2",

pages = "396--407",

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TY - JOUR

T1 - Non-contact spectroscopic determination of large blood volume fractions in turbid media

AU - Bremmer, R.H.

AU - Kanick, S.C.

AU - Laan, N.

AU - Amelink, A.

AU - van Leeuwen, Ton

AU - Aalders, M.C.G.

PY - 2011

Y1 - 2011

N2 - We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μa and μs′ on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms.

AB - We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μa and μs′ on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms.

KW - METIS-293100

KW - IR-83155

U2 - 10.1364/BOE.2.000396

DO - 10.1364/BOE.2.000396

M3 - Article

SN - 2156-7085

VL - 2

SP - 396

EP - 407

JO - Biomedical optics express

JF - Biomedical optics express

IS - 2

ER -

Non-contact spectroscopic determination of large blood volume fractions in turbid media

Abstract

Keywords

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