TY - JOUR
T1 - Non-invasive assessment of coronary artery geometry using coronary CTA
AU - Tuncay, V.
AU - Vliegenthart, R.
AU - Dekker, M.A.
AU - de Jonge, G. J.
AU - van Zandwijk, J. K.
AU - van der Harst, P.A.
AU - Oudkerk, Matthijs
AU - van Ooijen, P.M.A.
PY - 2018/5
Y1 - 2018/5
N2 - Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.
AB - Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.
KW - Atherosclerosis
KW - Coronary artery disease
KW - Coronary artery plaque
KW - Coronary computed tomography angiography
KW - Curvature
KW - Tortuosity
U2 - 10.1016/j.jcct.2018.02.003
DO - 10.1016/j.jcct.2018.02.003
M3 - Article
AN - SCOPUS:85042419246
VL - 12
SP - 257
EP - 260
JO - Journal of Cardiovascular Computed Tomography
JF - Journal of Cardiovascular Computed Tomography
SN - 1934-5925
IS - 3
ER -