Non-invasive assessment of coronary artery geometry using coronary CTA

V. Tuncay, R. Vliegenthart, M.A. Dekker, G. J. de Jonge, J. K. van Zandwijk, P.A. van der Harst, Matthijs Oudkerk, P.M.A. van Ooijen (Corresponding Author)

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Abstract

Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalJournal of Cardiovascular Computed Tomography
Volume12
Issue number3
DOIs
Publication statusPublished - May 2018

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Coronary Vessels
Pathologic Constriction
Arteries
Coronary Artery Disease
Peripheral Vascular Diseases
Computed Tomography Angiography
Linear Models

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Coronary artery plaque
  • Coronary computed tomography angiography
  • Curvature
  • Tortuosity

Cite this

Tuncay, V., Vliegenthart, R., Dekker, M. A., de Jonge, G. J., van Zandwijk, J. K., van der Harst, P. A., ... van Ooijen, P. M. A. (2018). Non-invasive assessment of coronary artery geometry using coronary CTA. Journal of Cardiovascular Computed Tomography, 12(3), 257-260. https://doi.org/10.1016/j.jcct.2018.02.003
Tuncay, V. ; Vliegenthart, R. ; Dekker, M.A. ; de Jonge, G. J. ; van Zandwijk, J. K. ; van der Harst, P.A. ; Oudkerk, Matthijs ; van Ooijen, P.M.A. / Non-invasive assessment of coronary artery geometry using coronary CTA. In: Journal of Cardiovascular Computed Tomography. 2018 ; Vol. 12, No. 3. pp. 257-260.
@article{076bd967eb774ceda520144b37c6ad37,
title = "Non-invasive assessment of coronary artery geometry using coronary CTA",
abstract = "Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70{\%} luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7{\%} higher for segments with stenosis, and 13.8{\%} higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.",
keywords = "Atherosclerosis, Coronary artery disease, Coronary artery plaque, Coronary computed tomography angiography, Curvature, Tortuosity",
author = "V. Tuncay and R. Vliegenthart and M.A. Dekker and {de Jonge}, {G. J.} and {van Zandwijk}, {J. K.} and {van der Harst}, P.A. and Matthijs Oudkerk and {van Ooijen}, P.M.A.",
year = "2018",
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Tuncay, V, Vliegenthart, R, Dekker, MA, de Jonge, GJ, van Zandwijk, JK, van der Harst, PA, Oudkerk, M & van Ooijen, PMA 2018, 'Non-invasive assessment of coronary artery geometry using coronary CTA', Journal of Cardiovascular Computed Tomography, vol. 12, no. 3, pp. 257-260. https://doi.org/10.1016/j.jcct.2018.02.003

Non-invasive assessment of coronary artery geometry using coronary CTA. / Tuncay, V.; Vliegenthart, R.; Dekker, M.A.; de Jonge, G. J.; van Zandwijk, J. K.; van der Harst, P.A.; Oudkerk, Matthijs; van Ooijen, P.M.A. (Corresponding Author).

In: Journal of Cardiovascular Computed Tomography, Vol. 12, No. 3, 05.2018, p. 257-260.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Non-invasive assessment of coronary artery geometry using coronary CTA

AU - Tuncay, V.

AU - Vliegenthart, R.

AU - Dekker, M.A.

AU - de Jonge, G. J.

AU - van Zandwijk, J. K.

AU - van der Harst, P.A.

AU - Oudkerk, Matthijs

AU - van Ooijen, P.M.A.

PY - 2018/5

Y1 - 2018/5

N2 - Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.

AB - Aim: To assess the association of coronary artery geometry with the severity of coronary artery disease (CAD). Methods: 73 asymptomatic individuals at increased risk of CAD due to peripheral vascular disease (18 women, mean age 63.5 ± 8.2 years) underwent coronary computed tomography angiography (coronary CTA) using first generation dual-source CT. Curvature and tortuosity of the coronary arteries were quantified using semi-automatically generated centerlines. Measurements were performed for individual segments and for the entire artery. Coronary segments were labeled according to the presence of significant stenosis, defined as >70% luminal narrowing, and the presence of plaque. Comparisons were made by segment and by artery, using linear mixed models. Results: Overall, median curvature and tortuosity were, respectively, 0.094 [0.071; 0.120] and 1.080 [1.040; 1.120] on a per-segment level, and 0.096 [0.078; 0.118] and 1.175 [1.090; 1.420] on a per-artery level. Curvature was associated with significant stenosis at a per-segment (p < 0.001) and per-artery level (p = 0.002). Curvature was 16.7% higher for segments with stenosis, and 13.8% higher for arteries with stenosis. Tortuosity was associated with significant stenosis only at the per-segment level (p = 0.002). Curvature was related to the presence of plaque at the per-segment (p < 0.001) and per-artery level (p < 0.001), tortuosity was only related to plaque at the per-segment level (p < 0.001). Conclusion: Coronary artery geometry as derived from coronary CTA is related to the presence of plaque and significant stenosis.

KW - Atherosclerosis

KW - Coronary artery disease

KW - Coronary artery plaque

KW - Coronary computed tomography angiography

KW - Curvature

KW - Tortuosity

U2 - 10.1016/j.jcct.2018.02.003

DO - 10.1016/j.jcct.2018.02.003

M3 - Article

AN - SCOPUS:85042419246

VL - 12

SP - 257

EP - 260

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 3

ER -