Non-invasive Imaging Biomarkers of Thyroid Nodules with Indeterminate Cytology

Wyanne A. Noortman; Elizabeth J. de Koster; Floris H.P. van Velden; Lioe Fee de Geus-Oei; Dennis Vriens

doi:10.1007/978-3-031-35213-3_5

Non-invasive Imaging Biomarkers of Thyroid Nodules with Indeterminate Cytology

Wyanne A. Noortman^*, Elizabeth J. de Koster, Floris H.P. van Velden, Lioe Fee de Geus-Oei, Dennis Vriens

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Abstract

Stratified by ultrasonography and fine-needle aspiration cytology, indeterminate nodules are lesions with an intermediate risk of being malignant (approximately 25%). Diagnostic resection of half the thyroid gland provides the true nature of these lesions but at the cost of 75% of the patients being futilely operated. In case a malignancy is found, a second surgery to remove the whole thyroid gland is often necessary. Different approaches either on cytological material or using imaging have been investigated to further stratify these lesions. This chapter reviewed biomarkers obtained using conventional as well as artificial intelligence-based non-invasive imaging strategies for the differentiation of thyroid nodules with indeterminate cytology. An overview of the abilities of different tests to differentiate between benign and malignant nodules was provided, taking into account the clinical readiness and cost-effectiveness.

Original language	English
Title of host publication	Integrated Diagnostics and Theranostics of Thyroid Diseases
Editors	Luca Giovanella
Publisher	Springer International Publishing
Pages	63-91
Number of pages	29
ISBN (Electronic)	9783031352133
ISBN (Print)	9783031352126
DOIs	https://doi.org/10.1007/978-3-031-35213-3_5
Publication status	Published - 4 Aug 2023

Keywords

Artificial intelligence
Imaging biomarkers
Indeterminate cytology
Medical imaging
Thyroid nodules

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978-3-031-35213-3_5Final published version, 1.84 MBLicence: CC BY

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abstract = "Stratified by ultrasonography and fine-needle aspiration cytology, indeterminate nodules are lesions with an intermediate risk of being malignant (approximately 25%). Diagnostic resection of half the thyroid gland provides the true nature of these lesions but at the cost of 75% of the patients being futilely operated. In case a malignancy is found, a second surgery to remove the whole thyroid gland is often necessary. Different approaches either on cytological material or using imaging have been investigated to further stratify these lesions. This chapter reviewed biomarkers obtained using conventional as well as artificial intelligence-based non-invasive imaging strategies for the differentiation of thyroid nodules with indeterminate cytology. An overview of the abilities of different tests to differentiate between benign and malignant nodules was provided, taking into account the clinical readiness and cost-effectiveness.",

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Non-invasive Imaging Biomarkers of Thyroid Nodules with Indeterminate Cytology. / Noortman, Wyanne A.; de Koster, Elizabeth J.; van Velden, Floris H.P. et al.
Integrated Diagnostics and Theranostics of Thyroid Diseases. ed. / Luca Giovanella. Springer International Publishing, 2023. p. 63-91.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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AU - de Koster, Elizabeth J.

AU - van Velden, Floris H.P.

AU - de Geus-Oei, Lioe Fee

AU - Vriens, Dennis

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AB - Stratified by ultrasonography and fine-needle aspiration cytology, indeterminate nodules are lesions with an intermediate risk of being malignant (approximately 25%). Diagnostic resection of half the thyroid gland provides the true nature of these lesions but at the cost of 75% of the patients being futilely operated. In case a malignancy is found, a second surgery to remove the whole thyroid gland is often necessary. Different approaches either on cytological material or using imaging have been investigated to further stratify these lesions. This chapter reviewed biomarkers obtained using conventional as well as artificial intelligence-based non-invasive imaging strategies for the differentiation of thyroid nodules with indeterminate cytology. An overview of the abilities of different tests to differentiate between benign and malignant nodules was provided, taking into account the clinical readiness and cost-effectiveness.

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Non-invasive Imaging Biomarkers of Thyroid Nodules with Indeterminate Cytology

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