Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women

Jan P. Vandenbroucke, Jacqueline C.M. Witteman, Hans A. Valkenburg, Johannnes W. Boersma, Arnold Cats, Johan J. Festen, Arend P. Hartman, Olga Huber-Bruning, Johannes J. Rasker, Jacobus Weber

    Research output: Contribution to journalArticleAcademicpeer-review

    111 Citations (Scopus)


    The use of noncontraceptive hormones before onset of joint disease was compared between 490 perimenopausal and postmenopausal women with rheumatoid arthritis and a control group of 659 women with soft-tissue rheumatologic disorders and/or osteoarthritis. Both groups were sampled randomly from the attendees of five rheumatologic clinics. A negative association was found between the onset of rheumatoid arthritis and the previous use of noncontraceptive hormones (odds ratio, 0.32%; 95% confidence interval, 0.16 to 0.64). This association persisted on univariate and multivariate control of potentially confounding variables and on subgroup analysis. The protective effect of oral contraceptives on the development of rheumatoid arthritis was confirmed.

    Original languageEnglish
    Pages (from-to)1299-1303
    Number of pages5
    JournalJAMA - Journal of the American Medical Association
    Issue number10
    Publication statusPublished - 3 Jun 1986


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