Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women

Jan P. Vandenbroucke, Jacqueline C.M. Witteman, Hans A. Valkenburg, Johannnes W. Boersma, Arnold Cats, Johan J. Festen, Arend P. Hartman, Olga Huber-Bruning, Johannes J. Rasker, Jacobus Weber

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Abstract

The use of noncontraceptive hormones before onset of joint disease was compared between 490 perimenopausal and postmenopausal women with rheumatoid arthritis and a control group of 659 women with soft-tissue rheumatologic disorders and/or osteoarthritis. Both groups were sampled randomly from the attendees of five rheumatologic clinics. A negative association was found between the onset of rheumatoid arthritis and the previous use of noncontraceptive hormones (odds ratio, 0.32%; 95% confidence interval, 0.16 to 0.64). This association persisted on univariate and multivariate control of potentially confounding variables and on subgroup analysis. The protective effect of oral contraceptives on the development of rheumatoid arthritis was confirmed.

Original languageEnglish
Pages (from-to)1299-1303
Number of pages5
JournalJournal of the American Medical Association (JAMA)
Volume255
Issue number10
DOIs
Publication statusPublished - 3 Jun 1986

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Rheumatoid Arthritis
Hormones
Confounding Factors (Epidemiology)
Joint Diseases
Oral Contraceptives
Osteoarthritis
Odds Ratio
Confidence Intervals
Control Groups

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Vandenbroucke, J. P., Witteman, J. C. M., Valkenburg, H. A., Boersma, J. W., Cats, A., Festen, J. J., ... Weber, J. (1986). Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. Journal of the American Medical Association (JAMA), 255(10), 1299-1303. https://doi.org/10.1001/jama.1986.03370100093024
Vandenbroucke, Jan P. ; Witteman, Jacqueline C.M. ; Valkenburg, Hans A. ; Boersma, Johannnes W. ; Cats, Arnold ; Festen, Johan J. ; Hartman, Arend P. ; Huber-Bruning, Olga ; Rasker, Johannes J. ; Weber, Jacobus. / Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. In: Journal of the American Medical Association (JAMA). 1986 ; Vol. 255, No. 10. pp. 1299-1303.
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Vandenbroucke, JP, Witteman, JCM, Valkenburg, HA, Boersma, JW, Cats, A, Festen, JJ, Hartman, AP, Huber-Bruning, O, Rasker, JJ & Weber, J 1986, 'Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women' Journal of the American Medical Association (JAMA), vol. 255, no. 10, pp. 1299-1303. https://doi.org/10.1001/jama.1986.03370100093024

Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. / Vandenbroucke, Jan P.; Witteman, Jacqueline C.M.; Valkenburg, Hans A.; Boersma, Johannnes W.; Cats, Arnold; Festen, Johan J.; Hartman, Arend P.; Huber-Bruning, Olga; Rasker, Johannes J.; Weber, Jacobus.

In: Journal of the American Medical Association (JAMA), Vol. 255, No. 10, 03.06.1986, p. 1299-1303.

Research output: Contribution to journalArticleAcademicpeer-review

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