Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Ying Luan; Guillaume Renaud; Jason L. Raymond; Robert Beurskens; Frits Mastik; Tom J.A. Kokhuis; Antonius F.W. van der Steen; Nico de Jong; Tim Segers; Guillaume P.R. Lajoinie; Michel Versluis

doi:10.1109/ULTSYM.2014.0443

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Ying Luan^*, Guillaume Renaud, Jason L. Raymond, Robert Beurskens, Frits Mastik, Tom J.A. Kokhuis, Antonius F.W. van der Steen, Nico de Jong, Tim Segers, Guillaume P.R. Lajoinie, Michel Versluis

^*Corresponding author for this work

Physics of Fluids

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

28 Downloads (Pure)

Abstract

The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε_2f, ε_3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (ε_f), the second harmonic response (ε_2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

Original language	English
Title of host publication	2014 IEEE International Ultrasonics Symposium (IUS)
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	1786-1789
Number of pages	4
ISBN (Electronic)	978-1-4799-7049-0
ISBN (Print)	978-1-4799-7048-3
DOIs	https://doi.org/10.1109/ULTSYM.2014.0443
Publication status	Published - 20 Oct 2014
Event	IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States Duration: 3 Sept 2014 → 6 Sept 2014

Publication series

Name	IEEE International Ultrasonics Symposium (IUS)
Publisher	IEEE
Volume	2014
ISSN (Print)	1051-0117

Conference

Conference	IEEE International Ultrasonics Symposium, IUS 2014
Abbreviated title	IKUS
Country/Territory	United States
City	Chicago
Period	3/09/14 → 6/09/14

Keywords

Freely-floating
Nonlinear
Optical sizing
Single microbubbles
2023 OA procedure

Access to Document

10.1109/ULTSYM.2014.0443

ArticleFinal published version, 359 KBLicence: Taverne

Cite this

Luan, Y., Renaud, G., Raymond, J. L., Beurskens, R., Mastik, F., Kokhuis, T. J. A., van der Steen, A. F. W., de Jong, N., Segers, T., Lajoinie, G. P. R., & Versluis, M. (2014). Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. In 2014 IEEE International Ultrasonics Symposium (IUS) (pp. 1786-1789). Article 6932224 (IEEE International Ultrasonics Symposium (IUS); Vol. 2014). IEEE. https://doi.org/10.1109/ULTSYM.2014.0443

@inproceedings{b204ce156dd84cceb2cb8fd5651d3fcc,

title = "Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation",

abstract = "The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.",

keywords = "Freely-floating, Nonlinear, Optical sizing, Single microbubbles, 2023 OA procedure",

author = "Ying Luan and Guillaume Renaud and Raymond, {Jason L.} and Robert Beurskens and Frits Mastik and Kokhuis, {Tom J.A.} and {van der Steen}, {Antonius F.W.} and {de Jong}, Nico and Tim Segers and Lajoinie, {Guillaume P.R.} and Michel Versluis",

year = "2014",

month = oct,

day = "20",

doi = "10.1109/ULTSYM.2014.0443",

language = "English",

isbn = "978-1-4799-7048-3",

series = "IEEE International Ultrasonics Symposium (IUS)",

publisher = "IEEE",

pages = "1786--1789",

booktitle = "2014 IEEE International Ultrasonics Symposium (IUS)",

address = "United States",

note = "IEEE International Ultrasonics Symposium, IUS 2014, IKUS ; Conference date: 03-09-2014 Through 06-09-2014",

}

Luan, Y, Renaud, G, Raymond, JL, Beurskens, R, Mastik, F, Kokhuis, TJA, van der Steen, AFW, de Jong, N, Segers, T , Lajoinie, GPR & Versluis, M 2014, Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. in 2014 IEEE International Ultrasonics Symposium (IUS)., 6932224, IEEE International Ultrasonics Symposium (IUS), vol. 2014, IEEE, Piscataway, NJ, pp. 1786-1789, IEEE International Ultrasonics Symposium, IUS 2014, Chicago, Illinois, United States, 3/09/14. https://doi.org/10.1109/ULTSYM.2014.0443

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. / Luan, Ying; Renaud, Guillaume; Raymond, Jason L. et al.
2014 IEEE International Ultrasonics Symposium (IUS). Piscataway, NJ: IEEE, 2014. p. 1786-1789 6932224 (IEEE International Ultrasonics Symposium (IUS); Vol. 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

AU - Luan, Ying

AU - Renaud, Guillaume

AU - Raymond, Jason L.

AU - Beurskens, Robert

AU - Mastik, Frits

AU - Kokhuis, Tom J.A.

AU - van der Steen, Antonius F.W.

AU - de Jong, Nico

AU - Segers, Tim

AU - Lajoinie, Guillaume P.R.

AU - Versluis, Michel

PY - 2014/10/20

Y1 - 2014/10/20

N2 - The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

AB - The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

KW - Freely-floating

KW - Nonlinear

KW - Optical sizing

KW - Single microbubbles

KW - 2023 OA procedure

UR - http://www.scopus.com/inward/record.url?scp=84910028714&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2014.0443

DO - 10.1109/ULTSYM.2014.0443

M3 - Conference contribution

AN - SCOPUS:84910028714

SN - 978-1-4799-7048-3

T3 - IEEE International Ultrasonics Symposium (IUS)

SP - 1786

EP - 1789

BT - 2014 IEEE International Ultrasonics Symposium (IUS)

PB - IEEE

CY - Piscataway, NJ

T2 - IEEE International Ultrasonics Symposium, IUS 2014

Y2 - 3 September 2014 through 6 September 2014

ER -

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

Cite this