Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Ying Luan*, Guillaume Renaud, Jason L. Raymond, Robert Beurskens, Frits Mastik, Tom J.A. Kokhuis, Antonius F.W. van der Steen, Nico de Jong, Tim Segers, Guillaume P.R. Lajoinie, Michel Versluis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

Original languageEnglish
Title of host publication2014 IEEE International Ultrasonics Symposium (IUS)
Subtitle of host publication3-6 Sept. 2014
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)978-1-4799-7049-0
ISBN (Print)978-1-4799-7048-3
Publication statusPublished - 20 Oct 2014
EventIEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: 3 Sep 20146 Sep 2014


ConferenceIEEE International Ultrasonics Symposium, IUS 2014
Abbreviated titleIKUS
Country/TerritoryUnited States


  • Freely-floating
  • Nonlinear
  • Optical sizing
  • Single microbubbles


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