Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

Ying Luan*, Guillaume Renaud, Jason L. Raymond, Robert Beurskens, Frits Mastik, Tom J.A. Kokhuis, Antonius F.W. van der Steen, Nico de Jong, Tim Segers, Guillaume P.R. Lajoinie, Michel Versluis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

Original languageEnglish
Title of host publication2014 IEEE International Ultrasonics Symposium (IUS)
Subtitle of host publication3-6 Sept. 2014
PublisherIEEE Computer Society
Pages1786-1789
Number of pages4
ISBN (Electronic)978-1-4799-7049-0
ISBN (Print)978-1-4799-7048-3
DOIs
Publication statusPublished - 20 Oct 2014
EventIEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: 3 Sep 20146 Sep 2014

Conference

ConferenceIEEE International Ultrasonics Symposium, IUS 2014
Abbreviated titleIKUS
CountryUnited States
CityChicago
Period3/09/146/09/14

Fingerprint

floating
bubbles
sizing
buckling
nonlinearity
asymmetry
optics
harmonics
vibration
oscillations
acoustics
simulation

Keywords

  • Freely-floating
  • Nonlinear
  • Optical sizing
  • Single microbubbles

Cite this

Luan, Y., Renaud, G., Raymond, J. L., Beurskens, R., Mastik, F., Kokhuis, T. J. A., ... Versluis, M. (2014). Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. In 2014 IEEE International Ultrasonics Symposium (IUS): 3-6 Sept. 2014 (pp. 1786-1789). [6932224] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0443
Luan, Ying ; Renaud, Guillaume ; Raymond, Jason L. ; Beurskens, Robert ; Mastik, Frits ; Kokhuis, Tom J.A. ; van der Steen, Antonius F.W. ; de Jong, Nico ; Segers, Tim ; Lajoinie, Guillaume P.R. ; Versluis, Michel. / Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. 2014 IEEE International Ultrasonics Symposium (IUS): 3-6 Sept. 2014. IEEE Computer Society, 2014. pp. 1786-1789
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title = "Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation",
abstract = "The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150{\%} stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.",
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author = "Ying Luan and Guillaume Renaud and Raymond, {Jason L.} and Robert Beurskens and Frits Mastik and Kokhuis, {Tom J.A.} and {van der Steen}, {Antonius F.W.} and {de Jong}, Nico and Tim Segers and Lajoinie, {Guillaume P.R.} and Michel Versluis",
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Luan, Y, Renaud, G, Raymond, JL, Beurskens, R, Mastik, F, Kokhuis, TJA, van der Steen, AFW, de Jong, N, Segers, T, Lajoinie, GPR & Versluis, M 2014, Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. in 2014 IEEE International Ultrasonics Symposium (IUS): 3-6 Sept. 2014., 6932224, IEEE Computer Society, pp. 1786-1789, IEEE International Ultrasonics Symposium, IUS 2014, Chicago, United States, 3/09/14. https://doi.org/10.1109/ULTSYM.2014.0443

Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. / Luan, Ying; Renaud, Guillaume; Raymond, Jason L.; Beurskens, Robert; Mastik, Frits; Kokhuis, Tom J.A.; van der Steen, Antonius F.W.; de Jong, Nico; Segers, Tim; Lajoinie, Guillaume P.R.; Versluis, Michel.

2014 IEEE International Ultrasonics Symposium (IUS): 3-6 Sept. 2014. IEEE Computer Society, 2014. p. 1786-1789 6932224.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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T1 - Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation

AU - Luan, Ying

AU - Renaud, Guillaume

AU - Raymond, Jason L.

AU - Beurskens, Robert

AU - Mastik, Frits

AU - Kokhuis, Tom J.A.

AU - van der Steen, Antonius F.W.

AU - de Jong, Nico

AU - Segers, Tim

AU - Lajoinie, Guillaume P.R.

AU - Versluis, Michel

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N2 - The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

AB - The acoustic nonlinear responses of ultrasound contrast agent microbubbles (MBs) are of great interest for both diagnostic and therapeutic applications. Previously, optical and acoustical methods were developed to characterize single bubbles floating against a rigid wall. However, there is a need to develop an efficient approach for statistical measurement of single freely-floating MBs. Here we combine simultaneous optical sizing and sensitive acoustical characterization measurement to study quantitatively the nonlinear dynamics of single freely-floating bubbles under prolonged ultrasound exposure. The nonlinearity (ε2f, ε3f) and asymmetry (i.e., compression-dominant behavior) of bubble vibrations were found to increase with increasing oscillation amplitude, and reach the maximum for bubbles at resonance. Moreover, with the same fundamental response (εf), the second harmonic response (ε2f) of bubbles smaller than the resonance size is 150% stronger than bubbles bigger than the resonance size. The data showed agreement with numerical simulations based on the shell-buckling model by Marmottant et al. The new system shows its great potential for in vitro characterization of contrast agent MB populations.

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M3 - Conference contribution

AN - SCOPUS:84910028714

SN - 978-1-4799-7048-3

SP - 1786

EP - 1789

BT - 2014 IEEE International Ultrasonics Symposium (IUS)

PB - IEEE Computer Society

ER -

Luan Y, Renaud G, Raymond JL, Beurskens R, Mastik F, Kokhuis TJA et al. Nonlinear dynamics of single freely-floating microbubbles under prolonged insonation. In 2014 IEEE International Ultrasonics Symposium (IUS): 3-6 Sept. 2014. IEEE Computer Society. 2014. p. 1786-1789. 6932224 https://doi.org/10.1109/ULTSYM.2014.0443