Nonlinear visual processing is faster in migraine with aura

Matthijs Perenboom, Yuan Yang, Johannes Carpay, Frans van der Helm, Michel Ferrari, Alfred Schouten, Else Tolner

    Research output: Contribution to journalArticleAcademicpeer-review

    1 Citation (Scopus)

    Abstract

    Objectives: Visual system abnormalities in migraine are linked to symptoms like photophobia and the visual aura. Little is known about the mechanisms contributing to these visual system alterations. Processing of visual input by the brain is a highly nonlinear operation, involving complex interactions among cortical and subcortical neuronal networks. Timing of this process can be estimated by analysing the cortical response to external light input at different frequencies. Using a sum-of-sinusoid light signal, instead of the classic pulse train, as input and novel EEG analyses it is possible to assess the time delay and frequency domain response. Here we investigate nonlinear visual processing in subgroups of migraine patients and headache-free participants.

    Methods: Migraine patients with aura, without aura and healthy participants (N = 10/group) were subjected to bi-sinusoidal light stimulation for 320 1 sec-epochs, while scalp EEG was recorded at the occipital, parietal and frontal lobes. Light stimulus frequencies were chosen to guarantee no overlap of their harmonic and intermodulation frequencies for different orders of nonlinearity. Nonlinear interactions and time delay from stimulus to cortical EEG response were analysed in the frequency domain using novel phase clustering measures and amplitude spectral measures.

    Results: Higher harmonic and intermodulation interactions were detected between visual input and cortical responses. Amplitude spectrum and phase clustering responses differed per order and group. Migraine patients with aura showed a decreased time delay only at the occipital lobe compared to healthy controls and migraine patients without aura.

    Conclusion: Visual processing is altered in migraine patients with aura compared to healthy controls and patients without aura. Furthermore, we demonstrated the potential of quantifying nonlinear interactions and temporal dynamics in the visual system using sum-of-sinusoid light stimulation. We are able to uncover alterations in visual processing in the context of neurological disease.
    Original languageEnglish
    Article numberPO-01-009
    Pages (from-to)56-57
    JournalCephalalgia
    Volume37
    Issue numberSuppl. 1
    DOIs
    Publication statusPublished - Sep 2017
    Event18th International Headache Congress, IHC 2017 - Vancouver Convention Centre, Vancouver, Canada
    Duration: 7 Sep 201710 Sep 2017
    Conference number: 18

    Cite this

    Perenboom, M., Yang, Y., Carpay, J., van der Helm, F., Ferrari, M., Schouten, A., & Tolner, E. (2017). Nonlinear visual processing is faster in migraine with aura. Cephalalgia, 37(Suppl. 1), 56-57. [PO-01-009]. https://doi.org/10.1177/0333102417719573
    Perenboom, Matthijs ; Yang, Yuan ; Carpay, Johannes ; van der Helm, Frans ; Ferrari, Michel ; Schouten, Alfred ; Tolner, Else. / Nonlinear visual processing is faster in migraine with aura. In: Cephalalgia. 2017 ; Vol. 37, No. Suppl. 1. pp. 56-57.
    @article{635f3f9135854e2fac38b076f482319b,
    title = "Nonlinear visual processing is faster in migraine with aura",
    abstract = "Objectives: Visual system abnormalities in migraine are linked to symptoms like photophobia and the visual aura. Little is known about the mechanisms contributing to these visual system alterations. Processing of visual input by the brain is a highly nonlinear operation, involving complex interactions among cortical and subcortical neuronal networks. Timing of this process can be estimated by analysing the cortical response to external light input at different frequencies. Using a sum-of-sinusoid light signal, instead of the classic pulse train, as input and novel EEG analyses it is possible to assess the time delay and frequency domain response. Here we investigate nonlinear visual processing in subgroups of migraine patients and headache-free participants.Methods: Migraine patients with aura, without aura and healthy participants (N = 10/group) were subjected to bi-sinusoidal light stimulation for 320 1 sec-epochs, while scalp EEG was recorded at the occipital, parietal and frontal lobes. Light stimulus frequencies were chosen to guarantee no overlap of their harmonic and intermodulation frequencies for different orders of nonlinearity. Nonlinear interactions and time delay from stimulus to cortical EEG response were analysed in the frequency domain using novel phase clustering measures and amplitude spectral measures.Results: Higher harmonic and intermodulation interactions were detected between visual input and cortical responses. Amplitude spectrum and phase clustering responses differed per order and group. Migraine patients with aura showed a decreased time delay only at the occipital lobe compared to healthy controls and migraine patients without aura.Conclusion: Visual processing is altered in migraine patients with aura compared to healthy controls and patients without aura. Furthermore, we demonstrated the potential of quantifying nonlinear interactions and temporal dynamics in the visual system using sum-of-sinusoid light stimulation. We are able to uncover alterations in visual processing in the context of neurological disease.",
    author = "Matthijs Perenboom and Yuan Yang and Johannes Carpay and {van der Helm}, Frans and Michel Ferrari and Alfred Schouten and Else Tolner",
    year = "2017",
    month = "9",
    doi = "10.1177/0333102417719573",
    language = "English",
    volume = "37",
    pages = "56--57",
    journal = "Cephalalgia",
    issn = "0333-1024",
    publisher = "SAGE Publications",
    number = "Suppl. 1",

    }

    Perenboom, M, Yang, Y, Carpay, J, van der Helm, F, Ferrari, M, Schouten, A & Tolner, E 2017, 'Nonlinear visual processing is faster in migraine with aura' Cephalalgia, vol. 37, no. Suppl. 1, PO-01-009, pp. 56-57. https://doi.org/10.1177/0333102417719573

    Nonlinear visual processing is faster in migraine with aura. / Perenboom, Matthijs; Yang, Yuan; Carpay, Johannes; van der Helm, Frans; Ferrari, Michel; Schouten, Alfred; Tolner, Else.

    In: Cephalalgia, Vol. 37, No. Suppl. 1, PO-01-009, 09.2017, p. 56-57.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Nonlinear visual processing is faster in migraine with aura

    AU - Perenboom, Matthijs

    AU - Yang, Yuan

    AU - Carpay, Johannes

    AU - van der Helm, Frans

    AU - Ferrari, Michel

    AU - Schouten, Alfred

    AU - Tolner, Else

    PY - 2017/9

    Y1 - 2017/9

    N2 - Objectives: Visual system abnormalities in migraine are linked to symptoms like photophobia and the visual aura. Little is known about the mechanisms contributing to these visual system alterations. Processing of visual input by the brain is a highly nonlinear operation, involving complex interactions among cortical and subcortical neuronal networks. Timing of this process can be estimated by analysing the cortical response to external light input at different frequencies. Using a sum-of-sinusoid light signal, instead of the classic pulse train, as input and novel EEG analyses it is possible to assess the time delay and frequency domain response. Here we investigate nonlinear visual processing in subgroups of migraine patients and headache-free participants.Methods: Migraine patients with aura, without aura and healthy participants (N = 10/group) were subjected to bi-sinusoidal light stimulation for 320 1 sec-epochs, while scalp EEG was recorded at the occipital, parietal and frontal lobes. Light stimulus frequencies were chosen to guarantee no overlap of their harmonic and intermodulation frequencies for different orders of nonlinearity. Nonlinear interactions and time delay from stimulus to cortical EEG response were analysed in the frequency domain using novel phase clustering measures and amplitude spectral measures.Results: Higher harmonic and intermodulation interactions were detected between visual input and cortical responses. Amplitude spectrum and phase clustering responses differed per order and group. Migraine patients with aura showed a decreased time delay only at the occipital lobe compared to healthy controls and migraine patients without aura.Conclusion: Visual processing is altered in migraine patients with aura compared to healthy controls and patients without aura. Furthermore, we demonstrated the potential of quantifying nonlinear interactions and temporal dynamics in the visual system using sum-of-sinusoid light stimulation. We are able to uncover alterations in visual processing in the context of neurological disease.

    AB - Objectives: Visual system abnormalities in migraine are linked to symptoms like photophobia and the visual aura. Little is known about the mechanisms contributing to these visual system alterations. Processing of visual input by the brain is a highly nonlinear operation, involving complex interactions among cortical and subcortical neuronal networks. Timing of this process can be estimated by analysing the cortical response to external light input at different frequencies. Using a sum-of-sinusoid light signal, instead of the classic pulse train, as input and novel EEG analyses it is possible to assess the time delay and frequency domain response. Here we investigate nonlinear visual processing in subgroups of migraine patients and headache-free participants.Methods: Migraine patients with aura, without aura and healthy participants (N = 10/group) were subjected to bi-sinusoidal light stimulation for 320 1 sec-epochs, while scalp EEG was recorded at the occipital, parietal and frontal lobes. Light stimulus frequencies were chosen to guarantee no overlap of their harmonic and intermodulation frequencies for different orders of nonlinearity. Nonlinear interactions and time delay from stimulus to cortical EEG response were analysed in the frequency domain using novel phase clustering measures and amplitude spectral measures.Results: Higher harmonic and intermodulation interactions were detected between visual input and cortical responses. Amplitude spectrum and phase clustering responses differed per order and group. Migraine patients with aura showed a decreased time delay only at the occipital lobe compared to healthy controls and migraine patients without aura.Conclusion: Visual processing is altered in migraine patients with aura compared to healthy controls and patients without aura. Furthermore, we demonstrated the potential of quantifying nonlinear interactions and temporal dynamics in the visual system using sum-of-sinusoid light stimulation. We are able to uncover alterations in visual processing in the context of neurological disease.

    U2 - 10.1177/0333102417719573

    DO - 10.1177/0333102417719573

    M3 - Article

    VL - 37

    SP - 56

    EP - 57

    JO - Cephalalgia

    JF - Cephalalgia

    SN - 0333-1024

    IS - Suppl. 1

    M1 - PO-01-009

    ER -

    Perenboom M, Yang Y, Carpay J, van der Helm F, Ferrari M, Schouten A et al. Nonlinear visual processing is faster in migraine with aura. Cephalalgia. 2017 Sep;37(Suppl. 1):56-57. PO-01-009. https://doi.org/10.1177/0333102417719573