Novel approach to sense oxygen in solution using short measurement times

F. van Rossem; T. Kamperman; J.G. Bomer; A. van den Berg; S. Le Gac; M. Boiani

doi:10.1109/ICSENS.2012.6411115

Novel approach to sense oxygen in solution using short measurement times

F. van Rossem^*, T. Kamperman, J.G. Bomer, A. van den Berg, S. Le Gac, M. Boiani

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

Abstract

We report here a novel approach for rapid sensing of oxygen in solution. Dissolved oxygen is measured using an ultramicroelectrode array (UMEA) (36 UMEs; 2μm O 20μm spacing) fabricated from Pt in an oxide-nitride-oxide insulating layer on glass. The oxygen concentration is determined in the short time measurement mode using the slope of the measured current I as a function of 1/√t (-0.4V applied), t being the measurement time (Cottrell equation). Specifically, the dissolved oxygen concentration is measured within less than 10ms in the solution. At the same time, the concentration in dissolved oxygen is monitored using an external optical sensor, for calibration purposes. A linear relationship (R²=0.96) is found between the responses of the two sensors. By implementing a conditioning step (0.1V applied for 10ms), only a 2% change is observed in the UMEA response over a 2h period. The proposed sensing approach will be very valuable to monitor in situ the respiratory activity of microtissues in nL volumes, as the amount of oxygen consumed by the sensor is dramatically decreased using short measurement times.

Original language	English
Title of host publication	IEEE SENSORS 2012 - Proceedings
DOIs	https://doi.org/10.1109/ICSENS.2012.6411115
Publication status	Published - 1 Dec 2012
Event	2012 IEEE Sensors - Taipei International Convention Center, Taipei, Taiwan Duration: 28 Oct 2012 → 31 Oct 2012

Conference

Conference	2012 IEEE Sensors
Country/Territory	Taiwan
City	Taipei
Period	28/10/12 → 31/10/12

Keywords

Electrodes
Current measurement
Sensor phenomena and characterization
Time measurement
Arrays
Atmospheric measurements

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title = "Novel approach to sense oxygen in solution using short measurement times",

abstract = "We report here a novel approach for rapid sensing of oxygen in solution. Dissolved oxygen is measured using an ultramicroelectrode array (UMEA) (36 UMEs; 2μm O 20μm spacing) fabricated from Pt in an oxide-nitride-oxide insulating layer on glass. The oxygen concentration is determined in the short time measurement mode using the slope of the measured current I as a function of 1/√t (-0.4V applied), t being the measurement time (Cottrell equation). Specifically, the dissolved oxygen concentration is measured within less than 10ms in the solution. At the same time, the concentration in dissolved oxygen is monitored using an external optical sensor, for calibration purposes. A linear relationship (R2=0.96) is found between the responses of the two sensors. By implementing a conditioning step (0.1V applied for 10ms), only a 2% change is observed in the UMEA response over a 2h period. The proposed sensing approach will be very valuable to monitor in situ the respiratory activity of microtissues in nL volumes, as the amount of oxygen consumed by the sensor is dramatically decreased using short measurement times.",

keywords = "Electrodes, Current measurement, Sensor phenomena and characterization, Time measurement, Arrays, Atmospheric measurements",

author = "{van Rossem}, F. and T. Kamperman and J.G. Bomer and {van den Berg}, A. and {Le Gac}, S. and M. Boiani",

year = "2012",

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day = "1",

doi = "10.1109/ICSENS.2012.6411115",

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AU - van Rossem, F.

AU - Kamperman, T.

AU - Bomer, J.G.

AU - van den Berg, A.

AU - Le Gac, S.

AU - Boiani, M.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - We report here a novel approach for rapid sensing of oxygen in solution. Dissolved oxygen is measured using an ultramicroelectrode array (UMEA) (36 UMEs; 2μm O 20μm spacing) fabricated from Pt in an oxide-nitride-oxide insulating layer on glass. The oxygen concentration is determined in the short time measurement mode using the slope of the measured current I as a function of 1/√t (-0.4V applied), t being the measurement time (Cottrell equation). Specifically, the dissolved oxygen concentration is measured within less than 10ms in the solution. At the same time, the concentration in dissolved oxygen is monitored using an external optical sensor, for calibration purposes. A linear relationship (R2=0.96) is found between the responses of the two sensors. By implementing a conditioning step (0.1V applied for 10ms), only a 2% change is observed in the UMEA response over a 2h period. The proposed sensing approach will be very valuable to monitor in situ the respiratory activity of microtissues in nL volumes, as the amount of oxygen consumed by the sensor is dramatically decreased using short measurement times.

AB - We report here a novel approach for rapid sensing of oxygen in solution. Dissolved oxygen is measured using an ultramicroelectrode array (UMEA) (36 UMEs; 2μm O 20μm spacing) fabricated from Pt in an oxide-nitride-oxide insulating layer on glass. The oxygen concentration is determined in the short time measurement mode using the slope of the measured current I as a function of 1/√t (-0.4V applied), t being the measurement time (Cottrell equation). Specifically, the dissolved oxygen concentration is measured within less than 10ms in the solution. At the same time, the concentration in dissolved oxygen is monitored using an external optical sensor, for calibration purposes. A linear relationship (R2=0.96) is found between the responses of the two sensors. By implementing a conditioning step (0.1V applied for 10ms), only a 2% change is observed in the UMEA response over a 2h period. The proposed sensing approach will be very valuable to monitor in situ the respiratory activity of microtissues in nL volumes, as the amount of oxygen consumed by the sensor is dramatically decreased using short measurement times.

KW - Electrodes

KW - Current measurement

KW - Sensor phenomena and characterization

KW - Time measurement

KW - Arrays

KW - Atmospheric measurements

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DO - 10.1109/ICSENS.2012.6411115

M3 - Conference contribution

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SN - 9781457717659

BT - IEEE SENSORS 2012 - Proceedings

T2 - 2012 IEEE Sensors

Y2 - 28 October 2012 through 31 October 2012

ER -

Novel approach to sense oxygen in solution using short measurement times

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Keywords

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