Numerical simulation of the influence of a left ventricular assist device on the cardiovascular system

G.J. Verkerke*, A.A. Geertsema, D. Mihaylov, P.K. Blanksma, G. Rakhorst

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

The PUCA (pulsatile catheter) pump is a left ventricular assist device (LVAD) capable of unloading the left ventricle (LV) and improving coronary flow by providing a counterpulsation effect. It consists of an extracorporeal located membrane pump, coupled to a transarterial catheter that enters the body via a superficial artery and ends in the LV. Blood is aspirated from the LV and pumped in the ascending aorta through the same catheter guided by a valve system. Timing and frequency of the PUCA pump influence its efficacy. To study the influence of several pump parameters a numerical model of the device and the circulatory system has been developed. Results of animal experiments were used to validate the model. Optimization studies resulted in a pump configuration with a stroke volume of 50 cc and pump:heart frequency mode of 1:2 that starts ejection at the beginning of diastole.

Original languageEnglish
Pages (from-to)765-773
Number of pages9
JournalInternational journal of artificial organs
Volume23
Issue number11
DOIs
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Keywords

  • Cardiovascular system
  • Left ventricle
  • LVAD
  • Mechanical circulatory support system
  • Numerical model

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