Numerical simulations of electrokinetically-driven capture of viral particles inside media of high ionic strength

Aristides Docoslis*, Bingbing Zhang, Matthew R. Tomkins, Jeffery A. Wood

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The increasing frequency of virus-related disease outbreaks creates a growing need for methods that permit rapid detection of infectious biological agents, such as viruses, within small sample volumes and without amplification of the agent. Surface-based biosensors emerge as a promising set of detection devices that are suitable for this purpose. Moreover, recent experimental studies have demonstrated that the detection capabilities of these sensors can be significantly enhanced when their operation is aided by AC electrokinetic effects (dielectrophoretic and AC electrohydrodynamic forces), which can cause accelerated transport and capture of biological agents on microelectrode platforms situated on the sensor's surface. The present study is concerned with the 3D modeling and simulation of the phenomena that govern viral transport to, and capture on, a microelectrode surface inside media of physiological ionic strength under the influence of a spatially non-uniform AC electric field. More specifically, the resulting force patterns (viscous and dielectrophoretic) on particles are assessed by using a finite element method-based simulation package (COMSOL Multiphysics®). The validity of the computer simulations is confirmed through experiments involving electrokinetically-directed capture of fluorescent sub-micron latex particles under the same conditions.

Original languageEnglish
Title of host publication2006 AIChE Annual Meeting
Number of pages8
Publication statusPublished - 1 Dec 2006
Externally publishedYes
Event2006 AIChE Annual Meeting - San Francisco, United States
Duration: 12 Nov 200617 Nov 2006

Publication series

NameAIChE Annual Meeting, Conference Proceedings

Conference

Conference2006 AIChE Annual Meeting
CountryUnited States
CitySan Francisco
Period12/11/0617/11/06

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    Docoslis, A., Zhang, B., Tomkins, M. R., & Wood, J. A. (2006). Numerical simulations of electrokinetically-driven capture of viral particles inside media of high ionic strength. In 2006 AIChE Annual Meeting (AIChE Annual Meeting, Conference Proceedings).