Observation of nociceptive detection thresholds and cortical evoked potentials: Go/no-go versus two-interval forced choice

Boudewijn van den Berg*, Leen Vanwinsen, G. Pezzali, Jan R. Buitenweg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
49 Downloads (Pure)

Abstract

Pain scientists and clinicians search for objective measures of altered nociceptive processing to study and stratify chronic pain patients. Nociceptive processing can be studied by observing a combination of nociceptive detection thresholds and evoked potentials. However, it is unknown whether the nociceptive detection threshold measured using a go-/no-go (GN) procedure can be biased by a response criterion. In this study, we compared nociceptive detection thresholds, psychometric slopes, and central evoked potentials obtained during a GN procedure with those obtained during a two-interval forced choice (2IFC) procedure to determine (1) if the nociceptive detection threshold during a GN procedure is biased by a criterion and (2) to determine if nociceptive evoked potentials observed in response to stimuli around the detection threshold are biased by a criterion. We found that the detection threshold was higher when assessed using a GN procedure in comparison with the 2IFC procedure. During a GN procedure, the average P2 component increased proportionally when averaged with respect to detection probability, but showed on-off behavior when averaged with respect to stimulus detection. During a 2IFC procedure, the average P2 component increased nonlinearly when averaged with respect to detection probability. These data suggest that nociceptive detection thresholds estimated using a GN procedure are subject to a response criterion.
Original languageEnglish
Pages (from-to)1359-1369
Number of pages11
JournalAttention, perception & psychophysics
Volume84
Early online date5 Apr 2022
DOIs
Publication statusPublished - May 2022

Keywords

  • Psychophysics
  • Pain
  • Nociception
  • Perceptual threshold
  • Detection threshold
  • Response criterion
  • Go/No-Go
  • 2-Interval forced choice
  • Electroencephalography
  • Evoked potential
  • EEG
  • UT-Hybrid-D

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