Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Grissel Trujillo-de Santiago, Roholah Sharifi, Kan Yue, Ehsan Shrizaei Sani, Sara Saheb Kashaf, Mario Moisés Alvarez, Jeroen Leijten, Ali Khademhosseini, Reza Dana, Nasim Annabi* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

59 Citations (Scopus)
367 Downloads (Pure)


Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

Original languageEnglish
Pages (from-to)345-367
Number of pages23
Publication statusPublished - 1 Mar 2019


  • Bioadhesives and sealants
  • Drug delivery
  • Natural and synthetic
  • Ocular


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