Off-pump no-touch technique: 3-year results compared with the SYNTAX trial

S.C. Arrigoni, G. Mecozzi, Jan G Grandjean, J.L. Hillege, A.P. Kappetein, M.A. Mariani

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

OBJECTIVES: A 3-year follow-up of a retrospective, single-centre clinical study of OPCAB (off-pump coronary artery bypass) no-touch technique with arterial composite grafts and an indirect comparison with clinical outcomes of the 3-year follow-up of the SYNTAX trial. METHODS: A total of 400 consecutive patients (‘all-comers’) who underwent OPCAB no-touch coronary surgery. Primary endpoint was 3-year MACCE (major adverse cardiovascular and cerebrovascular events). These results were compared with the randomized arms of the SYNTAX trial. RESULTS: The observed 3-year survival was 82.2%. The cumulative 3-year freedom from MACCE was 89.7%. The percentage of MACCE was significantly lower (P < 0.001) in the OPCAB no-touch group (10.3%) compared with both arms of the SYNTAX trial (20.2 and 28.0%, respectively). Repeat revascularization in the OPCAB no-touch group (4.3%) was significantly lower (P < 0.001) compared with both arms of the SYNTAX trial (10.7 and 19.7%, respectively). The percentage of stroke was significantly lower (P = 0.032) in the OPCAB no-touch group compared with the CABG arm in the SYNTAX trial (1.3 vs 3.4%). There was no significant difference of stroke rate between the OPCAB no-touch group and the PCI arm of the SYNTAX trial (1.3 vs 2%, P = 0.347). CONCLUSIONS: The results at the 3-year follow-up showed the safety and efficacy of OPCAB no-touch technique. The OPCAB no-touch technique may improve patients' outcome by minimizing the morbidity and the neurological complications. Prospective controlled trials are needed to confirm these results.
Original languageEnglish
Pages (from-to)601-604
Number of pages4
JournalInteractive cardiovascular and thoracic surgery
Volume20
Issue number5
DOIs
Publication statusPublished - 2015

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Off-Pump Coronary Artery Bypass
Touch
Arm
Stroke
Morbidity
Transplants
Safety
Survival

Keywords

  • METIS-310668
  • IR-100836

Cite this

Arrigoni, S.C. ; Mecozzi, G. ; Grandjean, Jan G ; Hillege, J.L. ; Kappetein, A.P. ; Mariani, M.A. / Off-pump no-touch technique: 3-year results compared with the SYNTAX trial. In: Interactive cardiovascular and thoracic surgery. 2015 ; Vol. 20, No. 5. pp. 601-604.
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abstract = "OBJECTIVES: A 3-year follow-up of a retrospective, single-centre clinical study of OPCAB (off-pump coronary artery bypass) no-touch technique with arterial composite grafts and an indirect comparison with clinical outcomes of the 3-year follow-up of the SYNTAX trial. METHODS: A total of 400 consecutive patients (‘all-comers’) who underwent OPCAB no-touch coronary surgery. Primary endpoint was 3-year MACCE (major adverse cardiovascular and cerebrovascular events). These results were compared with the randomized arms of the SYNTAX trial. RESULTS: The observed 3-year survival was 82.2{\%}. The cumulative 3-year freedom from MACCE was 89.7{\%}. The percentage of MACCE was significantly lower (P < 0.001) in the OPCAB no-touch group (10.3{\%}) compared with both arms of the SYNTAX trial (20.2 and 28.0{\%}, respectively). Repeat revascularization in the OPCAB no-touch group (4.3{\%}) was significantly lower (P < 0.001) compared with both arms of the SYNTAX trial (10.7 and 19.7{\%}, respectively). The percentage of stroke was significantly lower (P = 0.032) in the OPCAB no-touch group compared with the CABG arm in the SYNTAX trial (1.3 vs 3.4{\%}). There was no significant difference of stroke rate between the OPCAB no-touch group and the PCI arm of the SYNTAX trial (1.3 vs 2{\%}, P = 0.347). CONCLUSIONS: The results at the 3-year follow-up showed the safety and efficacy of OPCAB no-touch technique. The OPCAB no-touch technique may improve patients' outcome by minimizing the morbidity and the neurological complications. Prospective controlled trials are needed to confirm these results.",
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Off-pump no-touch technique: 3-year results compared with the SYNTAX trial. / Arrigoni, S.C.; Mecozzi, G.; Grandjean, Jan G; Hillege, J.L.; Kappetein, A.P.; Mariani, M.A.

In: Interactive cardiovascular and thoracic surgery, Vol. 20, No. 5, 2015, p. 601-604.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Off-pump no-touch technique: 3-year results compared with the SYNTAX trial

AU - Arrigoni, S.C.

AU - Mecozzi, G.

AU - Grandjean, Jan G

AU - Hillege, J.L.

AU - Kappetein, A.P.

AU - Mariani, M.A.

PY - 2015

Y1 - 2015

N2 - OBJECTIVES: A 3-year follow-up of a retrospective, single-centre clinical study of OPCAB (off-pump coronary artery bypass) no-touch technique with arterial composite grafts and an indirect comparison with clinical outcomes of the 3-year follow-up of the SYNTAX trial. METHODS: A total of 400 consecutive patients (‘all-comers’) who underwent OPCAB no-touch coronary surgery. Primary endpoint was 3-year MACCE (major adverse cardiovascular and cerebrovascular events). These results were compared with the randomized arms of the SYNTAX trial. RESULTS: The observed 3-year survival was 82.2%. The cumulative 3-year freedom from MACCE was 89.7%. The percentage of MACCE was significantly lower (P < 0.001) in the OPCAB no-touch group (10.3%) compared with both arms of the SYNTAX trial (20.2 and 28.0%, respectively). Repeat revascularization in the OPCAB no-touch group (4.3%) was significantly lower (P < 0.001) compared with both arms of the SYNTAX trial (10.7 and 19.7%, respectively). The percentage of stroke was significantly lower (P = 0.032) in the OPCAB no-touch group compared with the CABG arm in the SYNTAX trial (1.3 vs 3.4%). There was no significant difference of stroke rate between the OPCAB no-touch group and the PCI arm of the SYNTAX trial (1.3 vs 2%, P = 0.347). CONCLUSIONS: The results at the 3-year follow-up showed the safety and efficacy of OPCAB no-touch technique. The OPCAB no-touch technique may improve patients' outcome by minimizing the morbidity and the neurological complications. Prospective controlled trials are needed to confirm these results.

AB - OBJECTIVES: A 3-year follow-up of a retrospective, single-centre clinical study of OPCAB (off-pump coronary artery bypass) no-touch technique with arterial composite grafts and an indirect comparison with clinical outcomes of the 3-year follow-up of the SYNTAX trial. METHODS: A total of 400 consecutive patients (‘all-comers’) who underwent OPCAB no-touch coronary surgery. Primary endpoint was 3-year MACCE (major adverse cardiovascular and cerebrovascular events). These results were compared with the randomized arms of the SYNTAX trial. RESULTS: The observed 3-year survival was 82.2%. The cumulative 3-year freedom from MACCE was 89.7%. The percentage of MACCE was significantly lower (P < 0.001) in the OPCAB no-touch group (10.3%) compared with both arms of the SYNTAX trial (20.2 and 28.0%, respectively). Repeat revascularization in the OPCAB no-touch group (4.3%) was significantly lower (P < 0.001) compared with both arms of the SYNTAX trial (10.7 and 19.7%, respectively). The percentage of stroke was significantly lower (P = 0.032) in the OPCAB no-touch group compared with the CABG arm in the SYNTAX trial (1.3 vs 3.4%). There was no significant difference of stroke rate between the OPCAB no-touch group and the PCI arm of the SYNTAX trial (1.3 vs 2%, P = 0.347). CONCLUSIONS: The results at the 3-year follow-up showed the safety and efficacy of OPCAB no-touch technique. The OPCAB no-touch technique may improve patients' outcome by minimizing the morbidity and the neurological complications. Prospective controlled trials are needed to confirm these results.

KW - METIS-310668

KW - IR-100836

U2 - 10.1093/icvts/ivv012

DO - 10.1093/icvts/ivv012

M3 - Article

VL - 20

SP - 601

EP - 604

JO - Interactive cardiovascular and thoracic surgery

JF - Interactive cardiovascular and thoracic surgery

SN - 1569-9293

IS - 5

ER -