Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

Klazina Kooiman; Marcel R. Böhmer; Marcia Emmer; Hendrik J. Vos; Ceciel Chlon; William T. Shi; Christopher S. Hall; Suzanne H.P.M. de Winter; Karin Schroën; Michel Versluis; Nico de Jong; Annemieke van Wamel

doi:10.1109/ULTSYM.2008.0082

Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

Klazina Kooiman^*, Marcel R. Böhmer, Marcia Emmer, Hendrik J. Vos, Ceciel Chlon, William T. Shi, Christopher S. Hall, Suzanne H.P.M. de Winter, Karin Schroën, Michel Versluis, Nico de Jong, Annemieke van Wamel

^*Corresponding author for this work

Physics of Fluids

Research output: Contribution to journal › Conference article › Academic › peer-review

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Abstract

Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

Original language	English
Article number	4803253
Pages (from-to)	333-336
Number of pages	4
Journal	Proceedings of the IEEE Ultrasonics Symposium
DOIs	https://doi.org/10.1109/ULTSYM.2008.0082
Publication status	Published - 1 Dec 2008
Event	2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing International Convention Center, Beijing, China Duration: 2 Nov 2008 → 5 Nov 2008 http://ewh.ieee.org/conf/ius_2008/

Keywords

Diagnostic ultrasound
Lipophilic drug
Local drug delivery
Polymeric ultrasound contrast agent

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10.1109/ULTSYM.2008.0082

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Kooiman, K., Böhmer, M. R., Emmer, M., Vos, H. J., Chlon, C., Shi, W. T., Hall, C. S., de Winter, S. H. P. M., Schroën, K., Versluis, M., de Jong, N., & van Wamel, A. (2008). Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs. Proceedings of the IEEE Ultrasonics Symposium, 333-336. Article 4803253. https://doi.org/10.1109/ULTSYM.2008.0082

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title = "Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs",

abstract = "Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.",

keywords = "Diagnostic ultrasound, Lipophilic drug, Local drug delivery, Polymeric ultrasound contrast agent",

author = "Klazina Kooiman and B{\"o}hmer, {Marcel R.} and Marcia Emmer and Vos, {Hendrik J.} and Ceciel Chlon and Shi, {William T.} and Hall, {Christopher S.} and {de Winter}, {Suzanne H.P.M.} and Karin Schro{\"e}n and Michel Versluis and {de Jong}, Nico and {van Wamel}, Annemieke",

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doi = "10.1109/ULTSYM.2008.0082",

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AU - Kooiman, Klazina

AU - Böhmer, Marcel R.

AU - Emmer, Marcia

AU - Vos, Hendrik J.

AU - Chlon, Ceciel

AU - Shi, William T.

AU - Hall, Christopher S.

AU - de Winter, Suzanne H.P.M.

AU - Schroën, Karin

AU - Versluis, Michel

AU - de Jong, Nico

AU - van Wamel, Annemieke

PY - 2008/12/1

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N2 - Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

AB - Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

KW - Diagnostic ultrasound

KW - Lipophilic drug

KW - Local drug delivery

KW - Polymeric ultrasound contrast agent

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DO - 10.1109/ULTSYM.2008.0082

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AN - SCOPUS:67649340954

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JO - Proceedings of the IEEE Ultrasonics Symposium

JF - Proceedings of the IEEE Ultrasonics Symposium

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T2 - 2008 IEEE International Ultrasonics Symposium, IUS 2008

Y2 - 2 November 2008 through 5 November 2008

ER -

Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

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