Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

Klazina Kooiman*, Marcel R. Böhmer, Marcia Emmer, Hendrik J. Vos, Ceciel Chlon, William T. Shi, Christopher S. Hall, Suzanne H.P.M. de Winter, Karin Schroën, Michel Versluis, Nico de Jong, Annemieke van Wamel

*Corresponding author for this work

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Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

Original languageEnglish
Article number4803253
Pages (from-to)333-336
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Publication statusPublished - 1 Dec 2008
Event2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing International Convention Center, Beijing, China
Duration: 2 Nov 20085 Nov 2008


  • Diagnostic ultrasound
  • Lipophilic drug
  • Local drug delivery
  • Polymeric ultrasound contrast agent


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