Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

Klazina Kooiman*, Marcel R. Böhmer, Marcia Emmer, Hendrik J. Vos, Ceciel Chlon, William T. Shi, Christopher S. Hall, Suzanne H.P.M. de Winter, Karin Schroën, Michel Versluis, Nico de Jong, Annemieke van Wamel

*Corresponding author for this work

Research output: Contribution to journalConference articleAcademicpeer-review

Abstract

Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

Original languageEnglish
Article number4803253
Pages (from-to)333-336
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
DOIs
Publication statusPublished - 1 Dec 2008
Event2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing International Convention Center, Beijing, China
Duration: 2 Nov 20085 Nov 2008
http://ewh.ieee.org/conf/ius_2008/

Fingerprint

delivery
drugs
oils
releasing
therapy
gases

Keywords

  • Diagnostic ultrasound
  • Lipophilic drug
  • Local drug delivery
  • Polymeric ultrasound contrast agent

Cite this

Kooiman, K., Böhmer, M. R., Emmer, M., Vos, H. J., Chlon, C., Shi, W. T., ... van Wamel, A. (2008). Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs. Proceedings of the IEEE Ultrasonics Symposium, 333-336. [4803253]. https://doi.org/10.1109/ULTSYM.2008.0082
Kooiman, Klazina ; Böhmer, Marcel R. ; Emmer, Marcia ; Vos, Hendrik J. ; Chlon, Ceciel ; Shi, William T. ; Hall, Christopher S. ; de Winter, Suzanne H.P.M. ; Schroën, Karin ; Versluis, Michel ; de Jong, Nico ; van Wamel, Annemieke. / Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs. In: Proceedings of the IEEE Ultrasonics Symposium. 2008 ; pp. 333-336.
@article{45cfac4195544a8381b991d04f114953,
title = "Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs",
abstract = "Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.",
keywords = "Diagnostic ultrasound, Lipophilic drug, Local drug delivery, Polymeric ultrasound contrast agent",
author = "Klazina Kooiman and B{\"o}hmer, {Marcel R.} and Marcia Emmer and Vos, {Hendrik J.} and Ceciel Chlon and Shi, {William T.} and Hall, {Christopher S.} and {de Winter}, {Suzanne H.P.M.} and Karin Schro{\"e}n and Michel Versluis and {de Jong}, Nico and {van Wamel}, Annemieke",
year = "2008",
month = "12",
day = "1",
doi = "10.1109/ULTSYM.2008.0082",
language = "English",
pages = "333--336",
journal = "Proceedings of the IEEE International Ultrasonics Symposium",
issn = "1051-0117",
publisher = "IEEE",

}

Kooiman, K, Böhmer, MR, Emmer, M, Vos, HJ, Chlon, C, Shi, WT, Hall, CS, de Winter, SHPM, Schroën, K, Versluis, M, de Jong, N & van Wamel, A 2008, 'Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs', Proceedings of the IEEE Ultrasonics Symposium, pp. 333-336. https://doi.org/10.1109/ULTSYM.2008.0082

Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs. / Kooiman, Klazina; Böhmer, Marcel R.; Emmer, Marcia; Vos, Hendrik J.; Chlon, Ceciel; Shi, William T.; Hall, Christopher S.; de Winter, Suzanne H.P.M.; Schroën, Karin; Versluis, Michel; de Jong, Nico; van Wamel, Annemieke.

In: Proceedings of the IEEE Ultrasonics Symposium, 01.12.2008, p. 333-336.

Research output: Contribution to journalConference articleAcademicpeer-review

TY - JOUR

T1 - Oil-filled polymeric ultrasound contrast agent as local drug delivery system for lipophilic drugs

AU - Kooiman, Klazina

AU - Böhmer, Marcel R.

AU - Emmer, Marcia

AU - Vos, Hendrik J.

AU - Chlon, Ceciel

AU - Shi, William T.

AU - Hall, Christopher S.

AU - de Winter, Suzanne H.P.M.

AU - Schroën, Karin

AU - Versluis, Michel

AU - de Jong, Nico

AU - van Wamel, Annemieke

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

AB - Novel polymeric microcapsules, filled with a mixture of gas and oil, were produced and their potential as ultrasound contrast agent-based drug delivery system for lipophilic drugs was investigated. Microcapsules were synthesized that contained either no oil, were almost half-filled with oil, or were almost completely filled with oil. Mean number weighted diameters were between 1.22 and 1.31 μm. At a low MI (1 MHz, Place of 0.24 MPa), microcapsules typically compressed without cracking. At a high MI (1 MHz, Place of 0.51 MPa), microcapsules cracke, thereby releasing their content. Guidance and monitoring of therapy will be possible because the microcapsules were echogenic and stable at low MI. These microcapsules therefore have great potential as local drug delivery system for lipophilic drugs.

KW - Diagnostic ultrasound

KW - Lipophilic drug

KW - Local drug delivery

KW - Polymeric ultrasound contrast agent

UR - http://www.scopus.com/inward/record.url?scp=67649340954&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2008.0082

DO - 10.1109/ULTSYM.2008.0082

M3 - Conference article

AN - SCOPUS:67649340954

SP - 333

EP - 336

JO - Proceedings of the IEEE International Ultrasonics Symposium

JF - Proceedings of the IEEE International Ultrasonics Symposium

SN - 1051-0117

M1 - 4803253

ER -