On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetci particles in continuous flow

Nicole Pamme, Jan C.T. Eijkel, Andreas Manz

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    The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.
    Original languageUndefined
    Article number10.1016/j.jmmm.2006.04.008
    Pages (from-to)237-244
    Number of pages8
    JournalJournal of magnetism and magnetic materials
    Issue number10/2
    Publication statusPublished - Dec 2006


    • EWI-8355
    • BIOS-Micro/nanofluidics
    • METIS-237674
    • Micro-fluidics
    • Magnetophoresis
    • Magnetic microparticles
    • Magnetic separation
    • IR-63732

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