On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetci particles in continuous flow

Nicole Pamme; Jan C.T. Eijkel; Andreas Manz

doi:10.1016/j.jmmm.2006.04.008

On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetci particles in continuous flow

Nicole Pamme, Jan C.T. Eijkel, Andreas Manz

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.

Original language	Undefined
Article number	10.1016/j.jmmm.2006.04.008
Pages (from-to)	237-244
Number of pages	8
Journal	Journal of magnetism and magnetic materials
Volume	307
Issue number	10/2
DOIs	https://doi.org/10.1016/j.jmmm.2006.04.008
Publication status	Published - Dec 2006

Keywords

EWI-8355
BIOS-Micro/nanofluidics
METIS-237674
Micro-fluidics
Magnetophoresis
Magnetic microparticles
Magnetic separation
IR-63732

Access to Document

10.1016/j.jmmm.2006.04.008

http://eprints.eemcs.utwente.nl/secure2/8355/01/J._of_Magnetism_and...___-_On-chip_free-flow_magntetophoresis....pdf

Cite this

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title = "On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetci particles in continuous flow",

abstract = "The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.",

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author = "Nicole Pamme and Eijkel, {Jan C.T.} and Andreas Manz",

note = "10.1016/j.jmmm.2006.04.008 ",

year = "2006",

month = dec,

doi = "10.1016/j.jmmm.2006.04.008",

language = "Undefined",

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T1 - On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetci particles in continuous flow

AU - Pamme, Nicole

AU - Eijkel, Jan C.T.

AU - Manz, Andreas

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PY - 2006/12

Y1 - 2006/12

N2 - The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.

AB - The complete separation of mixtures of magnetic particles was achieved by on-chip free-flow magnetophoresis. In continuous flow, magnetic particles were deflected from the direction of larninar flow by a perpendicular magnetic field depending on their magnetic susceptibility and size and on the flow rate. 2.8 and 4.5 mu m superparamagnetic particles with magnetic susceptibilities of 1.1 X 10(-4) and 1.6 x 10(-4) m(3) kg(-1), respectively, could be completely separated from each other reproducibly. The separated particles were detected by video observation and also by on-chip laser light scattering. Potential applications of this separation method include sorting of magnetic micro- and nanoparticles as well as magnetically labelled cells.

KW - EWI-8355

KW - BIOS-Micro/nanofluidics

KW - METIS-237674

KW - Micro-fluidics

KW - Magnetophoresis

KW - Magnetic microparticles

KW - Magnetic separation

KW - IR-63732

U2 - 10.1016/j.jmmm.2006.04.008

DO - 10.1016/j.jmmm.2006.04.008

M3 - Article

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