On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets

Nikita Reznik*, Guillaume Lajoinie, Oleksandr Shpak, Erik C. Gelderblom, Ross Williams, Nico de Jong, Michel Versluis, Peter N. Burns

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
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The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice.
Original languageEnglish
Pages (from-to)1379-1384
JournalUltrasound in medicine and biology
Issue number6
Publication statusPublished - 22 Jan 2014


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