On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

Tom Kamperman*, Bas Van Loo, Melvin Gurian, Sieger Henke, Marcel Karperien, Jeroen Leijten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
112 Downloads (Pure)


Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and repositioning of the nozzles readily enables the production of monodisperse water-in-oil and oil-in-water emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with controlled diameters ranging from 10 to 1000 μm using a single microfluidic device.

Original languageEnglish
Pages (from-to)1977-1984
Number of pages8
JournalLab on a chip
Issue number11
Publication statusPublished - 7 Jun 2019

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