On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

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Abstract

Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and repositioning of the nozzles readily enables the production of monodisperse water-in-oil and oil-in-water emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with controlled diameters ranging from 10 to 1000 μm using a single microfluidic device.

Original languageEnglish
Pages (from-to)1977-1984
Number of pages8
JournalLab on a chip
Volume19
Issue number11
DOIs
Publication statusPublished - 7 Jun 2019

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Lab-On-A-Chip Devices
Microfluidics
Nozzles
Oils
Microtechnology
Water
Emulsions
Microspheres
Microfabrication
Technology

Cite this

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title = "On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials",
abstract = "Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and repositioning of the nozzles readily enables the production of monodisperse water-in-oil and oil-in-water emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with controlled diameters ranging from 10 to 1000 μm using a single microfluidic device.",
author = "Tom Kamperman and {Van Loo}, Bas and Melvin Gurian and Sieger Henke and Marcel Karperien and Jeroen Leijten",
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On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials. / Kamperman, Tom; Van Loo, Bas; Gurian, Melvin; Henke, Sieger; Karperien, Marcel; Leijten, Jeroen.

In: Lab on a chip, Vol. 19, No. 11, 07.06.2019, p. 1977-1984.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials

AU - Kamperman, Tom

AU - Van Loo, Bas

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AU - Leijten, Jeroen

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AB - Microfluidic manufacturing platforms have advanced the production of monodisperse, shape-controlled, and chemically defined micromaterials. However, conventional microfabrication platforms are typically designed and fabricated as single-purpose and single-use tools, which limits their efficiency, versatility, and overall potential. We here present an on-the-fly exchangeable nozzle concept that operates in a transparent, 3D, and reusable microfluidic device produced without cleanroom technology. The facile exchange and repositioning of the nozzles readily enables the production of monodisperse water-in-oil and oil-in-water emulsions, solid and core-shell microspheres, microfibers, and even Janus type micromaterials with controlled diameters ranging from 10 to 1000 μm using a single microfluidic device.

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