TY - JOUR
T1 - On the Horizon: Instructive nanomaterials hold the potential to mimic tissue complexity
AU - Barbieri, D.
AU - de Bruijn, Joost Dick
AU - van Blitterswijk, Clemens
AU - Yuan, Huipin
PY - 2014
Y1 - 2014
N2 - Our bodies have the amazing ability to self-trigger tissue regeneration when required to repair or renew tissues. Adult stem cells emerge from their niche and are instructed by local environmental factors to differentiate into the needed specific phenotypes once they have migrated to the target sites. For example, the complex weaving of collagen filaments composing the tissue framework not only offers nanoscaled topographical cues to cells but also its stiffness may influence their differentiation. Specific biomolecules, secreted by glands or other cells and transported by body fluids, also provide instructive indications to cells. In this sense, combinations of various physical and chemical stimuli at the micro- and nanoscale are crucial in regenerating tissues.
AB - Our bodies have the amazing ability to self-trigger tissue regeneration when required to repair or renew tissues. Adult stem cells emerge from their niche and are instructed by local environmental factors to differentiate into the needed specific phenotypes once they have migrated to the target sites. For example, the complex weaving of collagen filaments composing the tissue framework not only offers nanoscaled topographical cues to cells but also its stiffness may influence their differentiation. Specific biomolecules, secreted by glands or other cells and transported by body fluids, also provide instructive indications to cells. In this sense, combinations of various physical and chemical stimuli at the micro- and nanoscale are crucial in regenerating tissues.
KW - IR-89854
KW - METIS-302980
U2 - 10.1109/MPUL.2013.2296802
DO - 10.1109/MPUL.2013.2296802
M3 - Article
SN - 2154-2287
VL - 5
SP - 44
EP - 49
JO - IEEE pulse
JF - IEEE pulse
IS - 2
ER -