On the integration of a microdialysis-based microTAS with calibration facility on a silicon-glass sandwich

A.J. Sprenkels, Wouter Olthuis, Piet Bergveld

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    5 Citations (Scopus)
    26 Downloads (Pure)

    Abstract

    The integration is discussed of all parts of a microdialysis-based micro Total Analysis System or ¿TAS. In particular a microdialysis probe, a potentiometric and amperometric ion- and enzyme sensor and a calibration dosing pump have been developed separately using different precision machining techniques. By modifying and adapting these parts they can be realized in one generic technology consisting of a stack of a silicon and a glass wafer. The silicon wafer contains the double lumen microdialysis probe connections, a dosing pump chamber with meander formed cavities containing the calibration solutions and small cavities for both the potentiometric and amperometric sensor. The glass wafer contains all the electrical contacts and wires for the sensors, the pump and Interconnections. Both wafers are anodically bonded to each other, yielding a hermetically sealed liquid handling system
    Original languageEnglish
    Title of host publication1st Ann. Int. IEEE-EMBS Special Topic Conf. on Microtechnologies in Med. & Biol.
    Place of PublicationLyon, France
    PublisherIEEE
    Pages326-330
    Number of pages5
    ISBN (Print)0-7803-6603-4
    DOIs
    Publication statusPublished - 12 Oct 2000
    Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology 2000 - Lyon, France
    Duration: 12 Oct 200014 Oct 2000

    Other

    Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology 2000
    CountryFrance
    CityLyon
    Period12/10/0014/10/00

    Keywords

    • IR-16943
    • METIS-113828

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  • Cite this

    Sprenkels, A. J., Olthuis, W., & Bergveld, P. (2000). On the integration of a microdialysis-based microTAS with calibration facility on a silicon-glass sandwich. In 1st Ann. Int. IEEE-EMBS Special Topic Conf. on Microtechnologies in Med. & Biol. (pp. 326-330). Lyon, France: IEEE. https://doi.org/10.1109/MMB.2000.893797