Abstract
A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.
| Original language | English |
|---|---|
| Pages (from-to) | 7815-7817 |
| Number of pages | 3 |
| Journal | Chemical communications |
| Volume | 49 |
| Issue number | 71 |
| DOIs | |
| Publication status | Published - 8 Aug 2013 |
| Externally published | Yes |