One-pot squaric acid diester mediated aqueous protein conjugation

Frederik Wurm; Tobias Steinbach; Harm Anton Klok

doi:10.1039/c3cc44039g

One-pot squaric acid diester mediated aqueous protein conjugation

Frederik Wurm
, Tobias Steinbach
, Harm Anton Klok^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.

Original language	English
Pages (from-to)	7815-7817
Number of pages	3
Journal	Chemical communications
Volume	49
Issue number	71
DOIs	https://doi.org/10.1039/c3cc44039g
Publication status	Published - 8 Aug 2013
Externally published	Yes

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title = "One-pot squaric acid diester mediated aqueous protein conjugation",

abstract = "A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.",

author = "Frederik Wurm and Tobias Steinbach and Klok, \{Harm Anton\}",

year = "2013",

month = aug,

day = "8",

doi = "10.1039/c3cc44039g",

language = "English",

volume = "49",

pages = "7815--7817",

journal = "Chemical communications",

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T1 - One-pot squaric acid diester mediated aqueous protein conjugation

AU - Wurm, Frederik

AU - Steinbach, Tobias

AU - Klok, Harm Anton

PY - 2013/8/8

Y1 - 2013/8/8

N2 - A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.

AB - A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e.g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.

UR - https://www.scopus.com/pages/publications/84881396844

U2 - 10.1039/c3cc44039g

DO - 10.1039/c3cc44039g

M3 - Article

C2 - 23884200

AN - SCOPUS:84881396844

SN - 1359-7345

VL - 49

SP - 7815

EP - 7817

JO - Chemical communications

JF - Chemical communications

IS - 71

ER -

One-pot squaric acid diester mediated aqueous protein conjugation

Abstract

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