TY - JOUR
T1 - Opioid receptor ligand binding in the human striatum
T2 - II. Heterogeneous distribution of kappa opioid receptor labeled with [3H]bremazocine
AU - Vonkeman, Harald E.
AU - Voorn, Pieter
AU - Brady, Linda S.
AU - Berendse, Henk W.
AU - Richfield, Eric K.
PY - 1996/10/14
Y1 - 1996/10/14
N2 - Selective kappa opioid receptor autoradiography with [3H]bremazocine (BRM) was used to examine regional and subregional kappa receptor distribution patterns at five rostrocaudal levels through the human striatum. [3H]BRM binding densities were measured in the individual striatal nuclei and in subregions therein. The distribution of [3H]BRM binding sites was found to have a strongly heterogeneous character. At the regional level a rostral-to-caudal decrease in [3H]BRM binding densities was observed. Also, a dorsal-to-ventral differentiation was seen, with higher values in the ventral striatum, especially in the nucleus accumbens, and lower values in the dorsal parts of the caudate nucleus and putamen. These findings suggest an association of kappa receptor function with limbic-related processes in the ventral striatum. Along the ventral edge of the nucleus accumbens and putamen, specific domains with extremely high [3H]BRM binding values were identified.
AB - Selective kappa opioid receptor autoradiography with [3H]bremazocine (BRM) was used to examine regional and subregional kappa receptor distribution patterns at five rostrocaudal levels through the human striatum. [3H]BRM binding densities were measured in the individual striatal nuclei and in subregions therein. The distribution of [3H]BRM binding sites was found to have a strongly heterogeneous character. At the regional level a rostral-to-caudal decrease in [3H]BRM binding densities was observed. Also, a dorsal-to-ventral differentiation was seen, with higher values in the ventral striatum, especially in the nucleus accumbens, and lower values in the dorsal parts of the caudate nucleus and putamen. These findings suggest an association of kappa receptor function with limbic-related processes in the ventral striatum. Along the ventral edge of the nucleus accumbens and putamen, specific domains with extremely high [3H]BRM binding values were identified.
KW - Basal ganglia
KW - Kappa opioid receptor
KW - Nucleus accumbens
KW - Receptor autoradiography
UR - http://www.scopus.com/inward/record.url?scp=0029911474&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-9861(19961014)374:2<223::AID-CNE5>3.0.CO;2-4
DO - 10.1002/(SICI)1096-9861(19961014)374:2<223::AID-CNE5>3.0.CO;2-4
M3 - Article
C2 - 8906495
AN - SCOPUS:0029911474
SN - 0021-9967
VL - 374
SP - 223
EP - 229
JO - The Journal of comparative neurology
JF - The Journal of comparative neurology
IS - 2
ER -