Opioid receptor ligand binding in the human striatum: II. Heterogeneous distribution of kappa opioid receptor labeled with [3H]bremazocine

Harald E. Vonkeman, Pieter Voorn, Linda S. Brady, Henk W. Berendse, Eric K. Richfield*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

Selective kappa opioid receptor autoradiography with [3H]bremazocine (BRM) was used to examine regional and subregional kappa receptor distribution patterns at five rostrocaudal levels through the human striatum. [3H]BRM binding densities were measured in the individual striatal nuclei and in subregions therein. The distribution of [3H]BRM binding sites was found to have a strongly heterogeneous character. At the regional level a rostral-to-caudal decrease in [3H]BRM binding densities was observed. Also, a dorsal-to-ventral differentiation was seen, with higher values in the ventral striatum, especially in the nucleus accumbens, and lower values in the dorsal parts of the caudate nucleus and putamen. These findings suggest an association of kappa receptor function with limbic-related processes in the ventral striatum. Along the ventral edge of the nucleus accumbens and putamen, specific domains with extremely high [3H]BRM binding values were identified.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalJournal of comparative neurology
Volume374
Issue number2
DOIs
Publication statusPublished - 14 Oct 1996
Externally publishedYes

Keywords

  • Basal ganglia
  • Kappa opioid receptor
  • Nucleus accumbens
  • Receptor autoradiography

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