Optical characterization of individual liposome-loaded microbubbles

Ying Luan; Telli Faez; Ilya Skachkov; Erik Gelderblom; Bart Geers; Ine Lentacker; Ton van der Steen; Michel Versluis; Nico de Jong

doi:10.1109/ULTSYM.2011.0472

Optical characterization of individual liposome-loaded microbubbles

Ying Luan, Telli Faez, Ilya Skachkov, Erik Gelderblom, Bart Geers, Ine Lentacker, Ton van der Steen, Michel Versluis, Nico de Jong

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.

Original language	English
Title of host publication	2011 IEEE International Ultrasonics Symposium (IUS)
Subtitle of host publication	18-21 Oct. 2011
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	1890-1893
Number of pages	4
ISBN (Electronic)	978-1-4577-1252-4
ISBN (Print)	978-1-4577-1253-1
DOIs	https://doi.org/10.1109/ULTSYM.2011.0472
Publication status	Published - 2012
Event	IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, United States Duration: 18 Oct 2011 → 21 Oct 2011

Conference

Conference	IEEE International Ultrasonics Symposium, IUS 2011
Abbreviated title	IUS
Country/Territory	United States
City	Orlando
Period	18/10/11 → 21/10/11

Keywords

Liposome-loaded microbubbles
Shell properties
Drug delivery

Access to Document

10.1109/ULTSYM.2011.0472

Cite this

@inproceedings{8f5a1c9d02a347e3bef37a3a96a3a8c9,

title = "Optical characterization of individual liposome-loaded microbubbles",

abstract = "Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.",

keywords = "Liposome-loaded microbubbles, Shell properties, Drug delivery",

author = "Ying Luan and Telli Faez and Ilya Skachkov and Erik Gelderblom and Bart Geers and Ine Lentacker and {van der Steen}, Ton and Michel Versluis and {de Jong}, Nico",

year = "2012",

doi = "10.1109/ULTSYM.2011.0472",

language = "English",

isbn = "978-1-4577-1253-1",

pages = "1890--1893",

booktitle = "2011 IEEE International Ultrasonics Symposium (IUS)",

publisher = "IEEE",

note = "IEEE International Ultrasonics Symposium, IUS 2011, IUS ; Conference date: 18-10-2011 Through 21-10-2011",

}

Luan, Y, Faez, T, Skachkov, I, Gelderblom, E, Geers, B, Lentacker, I, van der Steen, T, Versluis, M & de Jong, N 2012, Optical characterization of individual liposome-loaded microbubbles. in 2011 IEEE International Ultrasonics Symposium (IUS): 18-21 Oct. 2011. IEEE, Piscataway, NJ, pp. 1890-1893, IEEE International Ultrasonics Symposium, IUS 2011, Orlando, Florida, United States, 18/10/11. https://doi.org/10.1109/ULTSYM.2011.0472

TY - GEN

T1 - Optical characterization of individual liposome-loaded microbubbles

AU - Luan, Ying

AU - Faez, Telli

AU - Skachkov, Ilya

AU - Gelderblom, Erik

AU - Geers, Bart

AU - Lentacker, Ine

AU - van der Steen, Ton

AU - Versluis, Michel

AU - de Jong, Nico

PY - 2012

Y1 - 2012

N2 - Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.

AB - Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.Newly developed liposome-loaded (LPS) microbubbles are characterized by comparing their oscillating response with standard phospholipid-coated (bare) microbubbles using the ultra-high speed imaging (Brandaris 128) camera. A study of the shell properties indicate nearly the same shell elasticity and a higher shell viscosity for LPS bubbles than for bare bubbles. A frequency and pressure-dependent bubble acoustical behavior study shows a higher threshold for the initiation of bubble vibrations for LPS bubbles. In addition, an “expansion-only” behavior was observed for up to 69% of the investigated LPS bubbles which mostly occurred at lower acoustic pressures (≤30 kPa). Liposome attachment stability were studied using fluorescence imaging. The internal relationship among morphological structure, shell properties and ultrasonic behavior of LPS bubbles by optical characterization facilitate preclinical study and clinical application of LPS bubbles in ultrasound triggered drug delivery system.

KW - Liposome-loaded microbubbles

KW - Shell properties

KW - Drug delivery

U2 - 10.1109/ULTSYM.2011.0472

DO - 10.1109/ULTSYM.2011.0472

M3 - Conference contribution

SN - 978-1-4577-1253-1

SP - 1890

EP - 1893

BT - 2011 IEEE International Ultrasonics Symposium (IUS)

PB - IEEE

CY - Piscataway, NJ

T2 - IEEE International Ultrasonics Symposium, IUS 2011

Y2 - 18 October 2011 through 21 October 2011

ER -

Optical characterization of individual liposome-loaded microbubbles

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Keywords

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