Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

Ronni Wessels, Daniel M. de Bruin, Dirk J. Faber, Simon Horenblas, Bas W.G. Van Rhijn, Andrew D. Vincent, Marc van Beurden, Ton G. Van Leeuwen, Theo J.M. Ruers

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Abstract

Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (μ oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, μ oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. Materials and Methods: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive patients with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer thickness and μ oct . Results were grouped according to histopathology reports. Results: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that epidermal layer thickness and attenuation coefficient was significantly different between benign and (pre) malignant tissue, respect ively, P = 0.001 and P < 0.001. Conclusion: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious penile lesions shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.
Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalUrology Annals
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Jan 2015

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Optical Coherence Tomography
Prospective Studies
Biopsy
Skin
Ambulatory Care Facilities
Research
Population

Keywords

  • Carcinoma in situ
  • imaging
  • optical coherence tomography
  • penile carcinoma
  • penile intraepithelial neoplasia

Cite this

Wessels, Ronni ; de Bruin, Daniel M. ; Faber, Dirk J. ; Horenblas, Simon ; Van Rhijn, Bas W.G. ; Vincent, Andrew D. ; van Beurden, Marc ; Van Leeuwen, Ton G. ; Ruers, Theo J.M. / Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study. In: Urology Annals. 2015 ; Vol. 7, No. 4. pp. 459-465.
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abstract = "Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (μ oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, μ oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. Materials and Methods: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive patients with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer thickness and μ oct . Results were grouped according to histopathology reports. Results: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that epidermal layer thickness and attenuation coefficient was significantly different between benign and (pre) malignant tissue, respect ively, P = 0.001 and P < 0.001. Conclusion: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious penile lesions shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.",
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author = "Ronni Wessels and {de Bruin}, {Daniel M.} and Faber, {Dirk J.} and Simon Horenblas and {Van Rhijn}, {Bas W.G.} and Vincent, {Andrew D.} and {van Beurden}, Marc and {Van Leeuwen}, {Ton G.} and Ruers, {Theo J.M.}",
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Wessels, R, de Bruin, DM, Faber, DJ, Horenblas, S, Van Rhijn, BWG, Vincent, AD, van Beurden, M, Van Leeuwen, TG & Ruers, TJM 2015, 'Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study', Urology Annals, vol. 7, no. 4, pp. 459-465. https://doi.org/10.4103/0974-7796.156147

Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study. / Wessels, Ronni; de Bruin, Daniel M.; Faber, Dirk J.; Horenblas, Simon; Van Rhijn, Bas W.G.; Vincent, Andrew D.; van Beurden, Marc; Van Leeuwen, Ton G.; Ruers, Theo J.M.

In: Urology Annals, Vol. 7, No. 4, 01.01.2015, p. 459-465.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

AU - Wessels, Ronni

AU - de Bruin, Daniel M.

AU - Faber, Dirk J.

AU - Horenblas, Simon

AU - Van Rhijn, Bas W.G.

AU - Vincent, Andrew D.

AU - van Beurden, Marc

AU - Van Leeuwen, Ton G.

AU - Ruers, Theo J.M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (μ oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, μ oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. Materials and Methods: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive patients with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer thickness and μ oct . Results were grouped according to histopathology reports. Results: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that epidermal layer thickness and attenuation coefficient was significantly different between benign and (pre) malignant tissue, respect ively, P = 0.001 and P < 0.001. Conclusion: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious penile lesions shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.

AB - Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (μ oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, μ oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. Materials and Methods: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive patients with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer thickness and μ oct . Results were grouped according to histopathology reports. Results: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that epidermal layer thickness and attenuation coefficient was significantly different between benign and (pre) malignant tissue, respect ively, P = 0.001 and P < 0.001. Conclusion: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious penile lesions shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.

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KW - imaging

KW - optical coherence tomography

KW - penile carcinoma

KW - penile intraepithelial neoplasia

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