Optical sensing for tissue differentiation

Daniel J. Evers

Research output: ThesisPhD Thesis - Research external, graduation UT

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Optical spectroscopy (OS) is a tissue sensing technique that could enhance cancer diagnosis and treatment in the near future. With OS, tissue is illuminated with a selected light spectrum. Different tissue types can be distinguished from each other based on specific changes in the reflected light spectrum that are a result of differences on a molecular level between compared tissues. Most practiced optical spectroscopy techniques are Diffuse Reflectance Spectroscopy (DRS) and Fluorescence Spectroscopy (FS). In a pre-­‐clinical phase, we designed and validated an optical console and specialized software for DRS and FS analysis of biological tissue. Our optical system comprises several advantages of compared to previous research. In this dissertation, we describe the initial results of this innovative approach for tissue differentiation in lung, liver and breast cancer and pave the way towards the incorporation of this technology into medical devices and introduction into every day medical procedures.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
  • Ruers, Theo J.M., Supervisor
  • Hendriks, Benno H.W., Co-Supervisor, External person
Award date10 Oct 2014
Place of PublicationEnschede
Print ISBNs978-94-6259-308-4
Publication statusPublished - 10 Oct 2014

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