Optical sensing in microfluidic lab-on-a-chip by femtosecond-laser-written waveguides

R. Martinez-Vazquez, R. Osellame*, M. Cretich, M. Chiari, C. Dongre, Hugo Hoekstra, Markus Pollnau, H.H. van den Vlekkert, R. Ramponi, G. Cerullo

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    28 Citations (Scopus)


    We use direct femtosecond laser writing to integrate optical waveguides into a commercial fused silica capillary electrophoresis chip. High-quality waveguides crossing the microfluidic channels are fabricated and used to optically address, with high spatial selectivity, their content. fluorescence from the optically excited volume is efficiently collected at a 90° angle by a high numerical aperture fiber, resulting in a highly compact and portable device. To test the platform we performed electrophoresis and detection of a 23-mer oligonucleotide plug. Our approach is quite powerful because it allows the integration of photonic functionalities, by simple post-processing, into commercial LOCs fabricated with standard techniques.
    Original languageEnglish
    Pages (from-to)1209-1216
    Number of pages8
    JournalAnalytical and bioanalytical chemistry
    Issue number4
    Publication statusPublished - Feb 2009




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