TY - JOUR
T1 - Optical sensing in microfluidic lab-on-a-chip by femtosecond-laser-written waveguides
AU - Martinez-Vazquez, R.
AU - Osellame, R.
AU - Cretich, M.
AU - Chiari, M.
AU - Dongre, C.
AU - Hoekstra, Hugo
AU - Pollnau, Markus
AU - van den Vlekkert, H.H.
AU - Ramponi, R.
AU - Cerullo, G.
PY - 2009/2
Y1 - 2009/2
N2 - We use direct femtosecond laser writing to integrate optical waveguides into a commercial fused silica capillary electrophoresis chip. High-quality waveguides crossing the microfluidic channels are fabricated and used to optically address, with high spatial selectivity, their content. fluorescence from the optically excited volume is efficiently collected at a 90° angle by a high numerical aperture fiber, resulting in a highly compact and portable device. To test the platform we performed electrophoresis and detection of a 23-mer oligonucleotide plug. Our approach is quite powerful because it allows the integration of photonic functionalities, by simple post-processing, into commercial LOCs fabricated with standard techniques.
AB - We use direct femtosecond laser writing to integrate optical waveguides into a commercial fused silica capillary electrophoresis chip. High-quality waveguides crossing the microfluidic channels are fabricated and used to optically address, with high spatial selectivity, their content. fluorescence from the optically excited volume is efficiently collected at a 90° angle by a high numerical aperture fiber, resulting in a highly compact and portable device. To test the platform we performed electrophoresis and detection of a 23-mer oligonucleotide plug. Our approach is quite powerful because it allows the integration of photonic functionalities, by simple post-processing, into commercial LOCs fabricated with standard techniques.
KW - IOMS-SNS: SENSORS
U2 - 10.1007/s00216-008-2399-8
DO - 10.1007/s00216-008-2399-8
M3 - Article
SN - 1618-2642
VL - 393
SP - 1209
EP - 1216
JO - Analytical and bioanalytical chemistry
JF - Analytical and bioanalytical chemistry
IS - 4
ER -