Optical trapping of ultrasound contrast agent microbubbles: Study of the bubble-wall and bubble-bubble interaction in ultrasound

V. Garbin*, E. Ferrari, D. Cojoc, E. Di Fabrizio, M. L.J. Overvelde, S. M. Van Der Meer, M. Versluis, N. De Jong, D. Lohse

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

7 Citations (Scopus)

Abstract

Here we present optical tweezers as a micromanipulation tool for the study of ultrasound contrast agent (UCA) microbubbles. Optical trapping and the resulting manipulation of individual and multiple microbubbles enables the study of their dynamics with controlled boundary conditions. The bubble response to ultrasound is recorded optically using the ultra high-speed Brandaris 128 camera. In our experiments, the amplitude of bubble oscillations was found to be strongly influenced by the vicinity of the sample chamber wall. Experiments with two trapped bubbles also showed a considerable influence of the neighboring bubble on the amplitude of oscillations of the other one.

Original languageEnglish
Title of host publication2006 IEEE International Ultrasonics Symposium, IUS
Pages513-516
Number of pages4
Volume1
DOIs
Publication statusPublished - 1 Dec 2006

Keywords

  • Bubble-to-bubble interactions
  • Microbubble dynamics
  • Optical tweezers
  • Ultrasound contrast agents

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