Optical tweezers stretching of chromatin

L.H. Pope, Martin L. Bennink, Jan Greve

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Recently significant success has emerged from exciting research involving chromatin stretching using optical tweezers. These experiments, in which a single chromatin fibre is attached by one end to a micron-sized bead held in an optical trap and to a solid surface or second bead via the other end, allows manipulation and force detection at a single-molecule level. Through force-induced stretching of chromatin, mechanical properties, specific inter-molecular bond strengths and DNA–protein association and dissociation kinetics have been determined. These studies will be extremely fruitful in terms of understanding the function of chromatin structure and its dynamics within the cell.
Original languageEnglish
Pages (from-to)397-407
Number of pages10
JournalJournal of muscle research and cell motility
Volume23
Issue number5-6
DOIs
Publication statusPublished - 2003

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