Abstract
Over the past years, extended antigen matching has become standard practice for some transfusion recipients and has proven to reduce alloimmunization risks. Inexpensive molecular typing has the potential to provide extended antigen matched red blood cell units to all transfusion recipients. It will alleviate unnecessary suffering which can result from the currently applied one-size-fits-all approach and will reduce costs of treatment by eliminating unintended side-effects.
By applying Operations Research techniques, we show that inventory issuing policies can be improved and evaluate the practical feasibility of extended antigen matching. The developed mathematical models are applied to case studies executed at the Dutch blood bank Sanquin.
By applying Operations Research techniques, we show that inventory issuing policies can be improved and evaluate the practical feasibility of extended antigen matching. The developed mathematical models are applied to case studies executed at the Dutch blood bank Sanquin.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 9 Dec 2020 |
Place of Publication | Enschede |
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Print ISBNs | 978-90-365-4983-7 |
DOIs | |
Publication status | Published - 9 Dec 2020 |
Keywords
- Mathematical optimization
- Operations research
- Blood transfusion
- Red blood cell matching