Optimal Red Blood Cell Matching

Josephus Henricus Jacobus van Sambeeck*

*Corresponding author for this work

Research output: ThesisPhD Thesis - Research external, graduation UT

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Over the past years, extended antigen matching has become standard practice for some transfusion recipients and has proven to reduce alloimmunization risks. Inexpensive molecular typing has the potential to provide extended antigen matched red blood cell units to all transfusion recipients. It will alleviate unnecessary suffering which can result from the currently applied one-size-fits-all approach and will reduce costs of treatment by eliminating unintended side-effects.
By applying Operations Research techniques, we show that inventory issuing policies can be improved and evaluate the practical feasibility of extended antigen matching. The developed mathematical models are applied to case studies executed at the Dutch blood bank Sanquin.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
  • van Dijk, N.M., Supervisor
  • de Kort, Wim L.A.M., Supervisor, External person
  • Janssen, M.P., Supervisor, External person
Thesis sponsors
Award date9 Dec 2020
Place of PublicationEnschede
Print ISBNs978-90-365-4983-7
Publication statusPublished - 9 Dec 2020


  • Mathematical optimization
  • Operations research
  • Blood transfusion
  • Red blood cell matching


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