Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging

G.J. Pelgrim, E.R. Nieuwenhuis, T. M. Duguay, R.J. van der Geest, A. Varga-Szemes, C.H. Slump, S.R. Fuller, Matthijs Oudkerk, U.J. Schoepf, R. Vliegenthart

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Abstract

Purpose To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. Methods and materials Twenty-five patients (59 ± 8.4 years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30 s at 100 kV and 300 mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments. The left ventricle (LV) wall was manually segmented according to the AHA 16-segment model. Hounsfield units (HU) in myocardial segments and ascending (AA) and descending aorta (AD) were monitored over time. Time difference between peak AA and peak AD and peak myocardial enhancement was calculated, as well as the, time delay from fixed HU thresholds of 150 and 250 HU in the AA and AD to a minimal difference of 15 HU between normal and ischemic segments. Furthermore, the duration of the 15 HU difference between ischemic and non-ischemic segments was calculated. Results Myocardial ischemia was observed by MRI in 10 patients (56.3 ± 9.0 years; 8 male). The delay between the maximum HU in the AA and AD and maximal HU in the non-ischemic segments was 2.8 s [2.2–4.3] and 0.0 s [0.0–2.8], respectively. Differentiation between ischemic and non-ischemic myocardial segments in CT was best during a time window of 8.6 ± 3.8 s. Time delays for AA triggering were 4.5 s [2.2–5.6] and 2.2 s [0–2.8] for the 150 HU and 250 HU thresholds, respectively. While for AD triggering, time delays were 2.4 s [0.0–4.8] and 0.0 s [−2.2–2.6] for the 150 HU and 250 HU thresholds, respectively. Conclusion In CTMPI, the differentiation between normal and ischemic myocardium is best accomplished during a time interval of 8.6 ± 3.8 s. This time window can be utilized by a test bolus or bolus tracking in the AA or AD using the time delays identified here.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalEuropean journal of radiology
Volume86
DOIs
Publication statusPublished - 1 Jan 2017

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Myocardial Perfusion Imaging
Tomography
Magnetic Resonance Angiography
Thoracic Aorta
Adenosine
Heart Ventricles
Myocardial Ischemia
Aorta
Myocardium
Magnetic Resonance Imaging

Keywords

  • Iodine
  • Ischemia
  • Myocardial perfusion imaging
  • Tomography
  • X-Ray computed

Cite this

Pelgrim, G.J. ; Nieuwenhuis, E.R. ; Duguay, T. M. ; van der Geest, R.J. ; Varga-Szemes, A. ; Slump, C.H. ; Fuller, S.R. ; Oudkerk, Matthijs ; Schoepf, U.J. ; Vliegenthart, R. / Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging. In: European journal of radiology. 2017 ; Vol. 86. pp. 227-233.
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title = "Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging",
abstract = "Purpose To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. Methods and materials Twenty-five patients (59 ± 8.4 years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30 s at 100 kV and 300 mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments. The left ventricle (LV) wall was manually segmented according to the AHA 16-segment model. Hounsfield units (HU) in myocardial segments and ascending (AA) and descending aorta (AD) were monitored over time. Time difference between peak AA and peak AD and peak myocardial enhancement was calculated, as well as the, time delay from fixed HU thresholds of 150 and 250 HU in the AA and AD to a minimal difference of 15 HU between normal and ischemic segments. Furthermore, the duration of the 15 HU difference between ischemic and non-ischemic segments was calculated. Results Myocardial ischemia was observed by MRI in 10 patients (56.3 ± 9.0 years; 8 male). The delay between the maximum HU in the AA and AD and maximal HU in the non-ischemic segments was 2.8 s [2.2–4.3] and 0.0 s [0.0–2.8], respectively. Differentiation between ischemic and non-ischemic myocardial segments in CT was best during a time window of 8.6 ± 3.8 s. Time delays for AA triggering were 4.5 s [2.2–5.6] and 2.2 s [0–2.8] for the 150 HU and 250 HU thresholds, respectively. While for AD triggering, time delays were 2.4 s [0.0–4.8] and 0.0 s [−2.2–2.6] for the 150 HU and 250 HU thresholds, respectively. Conclusion In CTMPI, the differentiation between normal and ischemic myocardium is best accomplished during a time interval of 8.6 ± 3.8 s. This time window can be utilized by a test bolus or bolus tracking in the AA or AD using the time delays identified here.",
keywords = "Iodine, Ischemia, Myocardial perfusion imaging, Tomography, X-Ray computed",
author = "G.J. Pelgrim and E.R. Nieuwenhuis and Duguay, {T. M.} and {van der Geest}, R.J. and A. Varga-Szemes and C.H. Slump and S.R. Fuller and Matthijs Oudkerk and U.J. Schoepf and R. Vliegenthart",
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Pelgrim, GJ, Nieuwenhuis, ER, Duguay, TM, van der Geest, RJ, Varga-Szemes, A, Slump, CH, Fuller, SR, Oudkerk, M, Schoepf, UJ & Vliegenthart, R 2017, 'Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging' European journal of radiology, vol. 86, pp. 227-233. https://doi.org/10.1016/j.ejrad.2016.11.024

Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging. / Pelgrim, G.J.; Nieuwenhuis, E.R.; Duguay, T. M.; van der Geest, R.J.; Varga-Szemes, A.; Slump, C.H.; Fuller, S.R.; Oudkerk, Matthijs; Schoepf, U.J.; Vliegenthart, R.

In: European journal of radiology, Vol. 86, 01.01.2017, p. 227-233.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Optimal timing of image acquisition for arterial first pass CT myocardial perfusion imaging

AU - Pelgrim, G.J.

AU - Nieuwenhuis, E.R.

AU - Duguay, T. M.

AU - van der Geest, R.J.

AU - Varga-Szemes, A.

AU - Slump, C.H.

AU - Fuller, S.R.

AU - Oudkerk, Matthijs

AU - Schoepf, U.J.

AU - Vliegenthart, R.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. Methods and materials Twenty-five patients (59 ± 8.4 years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30 s at 100 kV and 300 mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments. The left ventricle (LV) wall was manually segmented according to the AHA 16-segment model. Hounsfield units (HU) in myocardial segments and ascending (AA) and descending aorta (AD) were monitored over time. Time difference between peak AA and peak AD and peak myocardial enhancement was calculated, as well as the, time delay from fixed HU thresholds of 150 and 250 HU in the AA and AD to a minimal difference of 15 HU between normal and ischemic segments. Furthermore, the duration of the 15 HU difference between ischemic and non-ischemic segments was calculated. Results Myocardial ischemia was observed by MRI in 10 patients (56.3 ± 9.0 years; 8 male). The delay between the maximum HU in the AA and AD and maximal HU in the non-ischemic segments was 2.8 s [2.2–4.3] and 0.0 s [0.0–2.8], respectively. Differentiation between ischemic and non-ischemic myocardial segments in CT was best during a time window of 8.6 ± 3.8 s. Time delays for AA triggering were 4.5 s [2.2–5.6] and 2.2 s [0–2.8] for the 150 HU and 250 HU thresholds, respectively. While for AD triggering, time delays were 2.4 s [0.0–4.8] and 0.0 s [−2.2–2.6] for the 150 HU and 250 HU thresholds, respectively. Conclusion In CTMPI, the differentiation between normal and ischemic myocardium is best accomplished during a time interval of 8.6 ± 3.8 s. This time window can be utilized by a test bolus or bolus tracking in the AA or AD using the time delays identified here.

AB - Purpose To determine the optimal timing of arterial first pass computed tomography (CT) myocardial perfusion imaging (CTMPI) based on dynamic CTMPI acquisitions. Methods and materials Twenty-five patients (59 ± 8.4 years, 14 male)underwent adenosine-stress dynamic CTMPI on second-generation dual-source CT in shuttle mode (30 s at 100 kV and 300 mAs). Stress perfusion magnetic resonance imaging (MRI) was used as reference standard for differentiation of non-ischemic and ischemic segments. The left ventricle (LV) wall was manually segmented according to the AHA 16-segment model. Hounsfield units (HU) in myocardial segments and ascending (AA) and descending aorta (AD) were monitored over time. Time difference between peak AA and peak AD and peak myocardial enhancement was calculated, as well as the, time delay from fixed HU thresholds of 150 and 250 HU in the AA and AD to a minimal difference of 15 HU between normal and ischemic segments. Furthermore, the duration of the 15 HU difference between ischemic and non-ischemic segments was calculated. Results Myocardial ischemia was observed by MRI in 10 patients (56.3 ± 9.0 years; 8 male). The delay between the maximum HU in the AA and AD and maximal HU in the non-ischemic segments was 2.8 s [2.2–4.3] and 0.0 s [0.0–2.8], respectively. Differentiation between ischemic and non-ischemic myocardial segments in CT was best during a time window of 8.6 ± 3.8 s. Time delays for AA triggering were 4.5 s [2.2–5.6] and 2.2 s [0–2.8] for the 150 HU and 250 HU thresholds, respectively. While for AD triggering, time delays were 2.4 s [0.0–4.8] and 0.0 s [−2.2–2.6] for the 150 HU and 250 HU thresholds, respectively. Conclusion In CTMPI, the differentiation between normal and ischemic myocardium is best accomplished during a time interval of 8.6 ± 3.8 s. This time window can be utilized by a test bolus or bolus tracking in the AA or AD using the time delays identified here.

KW - Iodine

KW - Ischemia

KW - Myocardial perfusion imaging

KW - Tomography

KW - X-Ray computed

U2 - 10.1016/j.ejrad.2016.11.024

DO - 10.1016/j.ejrad.2016.11.024

M3 - Article

VL - 86

SP - 227

EP - 233

JO - European journal of radiology

JF - European journal of radiology

SN - 0720-048X

ER -