Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Muneer Ahmed; Bauke Anninga; Joost J. Pouw; Suzan Vreemann; Mirjam Peek; Mieke van Hemelrijck; Sarah Pinder; Bennie ten Haken; Quentin Pankhurst; Michael Douek

doi:10.1016/j.nano.2015.01.010

Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Muneer Ahmed, Bauke Anninga, Joost J. Pouw, Suzan Vreemann, Mirjam Peek, Mieke van Hemelrijck, Sarah Pinder, Bennie ten Haken, Quentin Pankhurst, Michael Douek^*

^*Corresponding author for this work

Magnetic Detection and Imaging

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was a significant correlation between magnetometer counts and iron content of excised sentinel lymph nodes (SLNs) (r = 0.82; P < 0.001). Total number of SLNs increased with increasing volumes of magnetic tracer (P < 0.001). Transcutaneous magnetometer counts increased with increasing time from injection of magnetic tracer (P < 0.0001), plateauing within 60 min. Increasing concentration resulted in higher iron content of SLNs (P = 0.006). Increasing magnetic tracer volume and injecting prior to surgery improve transcutaneous ‘hotspot’ identification but very high volumes, increase the number of nodes excised

Original language	English
Pages (from-to)	993-1002
Number of pages	10
Journal	Nanomedicine : nanotechnology, biology and medicine
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/j.nano.2015.01.010
Publication status	Published - 1 May 2015

Keywords

Magnetic tracer
Sentinel lymph node biopsy
SLNB: magnetic technique
SPIO
Superparamagnetic iron oxide
2023 OA procedure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nano.2015.01.010

ArticleFinal published version, 1.18 MBLicence: Taverne

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title = "Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model",

abstract = "The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was a significant correlation between magnetometer counts and iron content of excised sentinel lymph nodes (SLNs) (r = 0.82; P < 0.001). Total number of SLNs increased with increasing volumes of magnetic tracer (P < 0.001). Transcutaneous magnetometer counts increased with increasing time from injection of magnetic tracer (P < 0.0001), plateauing within 60 min. Increasing concentration resulted in higher iron content of SLNs (P = 0.006). Increasing magnetic tracer volume and injecting prior to surgery improve transcutaneous {\textquoteleft}hotspot{\textquoteright} identification but very high volumes, increase the number of nodes excised",

keywords = "Magnetic tracer, Sentinel lymph node biopsy, SLNB: magnetic technique, SPIO, Superparamagnetic iron oxide, 2023 OA procedure",

author = "Muneer Ahmed and Bauke Anninga and Pouw, {Joost J.} and Suzan Vreemann and Mirjam Peek and {van Hemelrijck}, Mieke and Sarah Pinder and {ten Haken}, Bennie and Quentin Pankhurst and Michael Douek",

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year = "2015",

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doi = "10.1016/j.nano.2015.01.010",

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AU - Ahmed, Muneer

AU - Anninga, Bauke

AU - Pouw, Joost J.

AU - Vreemann, Suzan

AU - Peek, Mirjam

AU - van Hemelrijck, Mieke

AU - Pinder, Sarah

AU - ten Haken, Bennie

AU - Pankhurst, Quentin

AU - Douek, Michael

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was a significant correlation between magnetometer counts and iron content of excised sentinel lymph nodes (SLNs) (r = 0.82; P < 0.001). Total number of SLNs increased with increasing volumes of magnetic tracer (P < 0.001). Transcutaneous magnetometer counts increased with increasing time from injection of magnetic tracer (P < 0.0001), plateauing within 60 min. Increasing concentration resulted in higher iron content of SLNs (P = 0.006). Increasing magnetic tracer volume and injecting prior to surgery improve transcutaneous ‘hotspot’ identification but very high volumes, increase the number of nodes excised

AB - The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was a significant correlation between magnetometer counts and iron content of excised sentinel lymph nodes (SLNs) (r = 0.82; P < 0.001). Total number of SLNs increased with increasing volumes of magnetic tracer (P < 0.001). Transcutaneous magnetometer counts increased with increasing time from injection of magnetic tracer (P < 0.0001), plateauing within 60 min. Increasing concentration resulted in higher iron content of SLNs (P = 0.006). Increasing magnetic tracer volume and injecting prior to surgery improve transcutaneous ‘hotspot’ identification but very high volumes, increase the number of nodes excised

KW - Magnetic tracer

KW - Sentinel lymph node biopsy

KW - SLNB: magnetic technique

KW - SPIO

KW - Superparamagnetic iron oxide

KW - 2023 OA procedure

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ER -

Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Abstract

Keywords

UN SDGs

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