Optimization of stripline-based microfluidic chips for high-resolution NMR

J. Bart, J.W.G. Janssen, P.J.M. van Bentum, A.P.M. Kentgens, Johannes G.E. Gardeniers

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)
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Abstract

We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/√Hz and a resolution of 0.7 Hz. The rf-homogeneity (A810°/A90°) was 76% and was proved to be suitable for 2D-NMR analysis of glucose.
Original languageEnglish
Pages (from-to)175-185
Number of pages11
JournalJournal of magnetic resonance
Volume201
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Lab on a chip
  • Stripline
  • IR-80079
  • Microfluidic
  • Microcoil
  • METIS-260099

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