Optimization of stripline-based microfluidic chips for high-resolution NMR

J. Bart; J.W.G. Janssen; P.J.M. van Bentum; A.P.M. Kentgens; Johannes G.E. Gardeniers

doi:10.1016/j.jmr.2009.09.007

Optimization of stripline-based microfluidic chips for high-resolution NMR

J. Bart, J.W.G. Janssen, P.J.M. van Bentum, A.P.M. Kentgens, Johannes G.E. Gardeniers

Mesoscale Chemical Systems

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Abstract

We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/√Hz and a resolution of 0.7 Hz. The rf-homogeneity (A810°/A90°) was 76% and was proved to be suitable for 2D-NMR analysis of glucose.

Original language	English
Pages (from-to)	175-185
Number of pages	11
Journal	Journal of magnetic resonance
Volume	201
Issue number	2
DOIs	https://doi.org/10.1016/j.jmr.2009.09.007
Publication status	Published - 2009

Keywords

Lab on a chip
Stripline
IR-80079
Microfluidic
Microcoil
METIS-260099

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10.1016/j.jmr.2009.09.007

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title = "Optimization of stripline-based microfluidic chips for high-resolution NMR",

abstract = "We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/√Hz and a resolution of 0.7 Hz. The rf-homogeneity (A810°/A90°) was 76% and was proved to be suitable for 2D-NMR analysis of glucose.",

keywords = "Lab on a chip, Stripline, IR-80079, Microfluidic, Microcoil, METIS-260099",

author = "J. Bart and J.W.G. Janssen and {van Bentum}, P.J.M. and A.P.M. Kentgens and Gardeniers, {Johannes G.E.}",

year = "2009",

doi = "10.1016/j.jmr.2009.09.007",

language = "English",

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pages = "175--185",

journal = "Journal of magnetic resonance",

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TY - JOUR

T1 - Optimization of stripline-based microfluidic chips for high-resolution NMR

AU - Bart, J.

AU - Janssen, J.W.G.

AU - van Bentum, P.J.M.

AU - Kentgens, A.P.M.

AU - Gardeniers, Johannes G.E.

PY - 2009

Y1 - 2009

N2 - We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/√Hz and a resolution of 0.7 Hz. The rf-homogeneity (A810°/A90°) was 76% and was proved to be suitable for 2D-NMR analysis of glucose.

AB - We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/√Hz and a resolution of 0.7 Hz. The rf-homogeneity (A810°/A90°) was 76% and was proved to be suitable for 2D-NMR analysis of glucose.

KW - Lab on a chip

KW - Stripline

KW - IR-80079

KW - Microfluidic

KW - Microcoil

KW - METIS-260099

U2 - 10.1016/j.jmr.2009.09.007

DO - 10.1016/j.jmr.2009.09.007

M3 - Article

SN - 1090-7807

VL - 201

SP - 175

EP - 185

JO - Journal of magnetic resonance

JF - Journal of magnetic resonance

IS - 2

ER -

Optimization of stripline-based microfluidic chips for high-resolution NMR

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Keywords

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