Organometallic polymeric carriers for redox triggered release of molecular payloads

Dominik Jańczewski; Jing Song; Erzsébet Csányi; Lóránd Kiss; Péter Blazsó; Róbert L. Katona; Mária A. Deli; Guillaume Gros; Jianwei Xu; G. Julius Vancso

doi:10.1039/C2JM15755A

Organometallic polymeric carriers for redox triggered release of molecular payloads

Dominik Jańczewski, Jing Song, Erzsébet Csányi, Lóránd Kiss, Péter Blazsó, Róbert L. Katona, Mária A. Deli, Guillaume Gros, Jianwei Xu, G. Julius Vancso^*

^*Corresponding author for this work

Faculty of Science and Technology

Research output: Contribution to journal › Article › Academic › peer-review

40 Citations (Scopus)

Abstract

The synthesis and characterization of a novel redox responsive comb-copolymer consisting of a poly(ferrocenylsilane) backbone and N-dimethylethyl ammonium and N-dimethyldecyl ammonium substituents are reported. Due to the presence of the side groups featuring cationic amine as well as decyl hydrocarbon chains the comb copolymer exhibits amphiphilic behaviour and forms micellar assemblies with typical dimensions of 100 nm. The assemblies display unique, redox induced morphology change in water, investigated by dynamic light scattering and transmission electron microscopy. Paclitaxel and Nile Red were encapsulated in the micelles as model guest molecular payloads. Release of the guests with a high degree of profile control by varying the concentration of redox agents is presented.

Original language	English
Pages (from-to)	6429-6435
Number of pages	7
Journal	Journal of materials chemistry
Volume	22
Issue number	13
DOIs	https://doi.org/10.1039/C2JM15755A
Publication status	Published - 2012

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title = "Organometallic polymeric carriers for redox triggered release of molecular payloads",

abstract = "The synthesis and characterization of a novel redox responsive comb-copolymer consisting of a poly(ferrocenylsilane) backbone and N-dimethylethyl ammonium and N-dimethyldecyl ammonium substituents are reported. Due to the presence of the side groups featuring cationic amine as well as decyl hydrocarbon chains the comb copolymer exhibits amphiphilic behaviour and forms micellar assemblies with typical dimensions of 100 nm. The assemblies display unique, redox induced morphology change in water, investigated by dynamic light scattering and transmission electron microscopy. Paclitaxel and Nile Red were encapsulated in the micelles as model guest molecular payloads. Release of the guests with a high degree of profile control by varying the concentration of redox agents is presented.",

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year = "2012",

doi = "10.1039/C2JM15755A",

language = "English",

volume = "22",

pages = "6429--6435",

journal = "Journal of materials chemistry",

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TY - JOUR

T1 - Organometallic polymeric carriers for redox triggered release of molecular payloads

AU - Jańczewski, Dominik

AU - Song, Jing

AU - Csányi, Erzsébet

AU - Kiss, Lóránd

AU - Blazsó, Péter

AU - Katona, Róbert L.

AU - Deli, Mária A.

AU - Gros, Guillaume

AU - Xu, Jianwei

AU - Vancso, G. Julius

PY - 2012

Y1 - 2012

N2 - The synthesis and characterization of a novel redox responsive comb-copolymer consisting of a poly(ferrocenylsilane) backbone and N-dimethylethyl ammonium and N-dimethyldecyl ammonium substituents are reported. Due to the presence of the side groups featuring cationic amine as well as decyl hydrocarbon chains the comb copolymer exhibits amphiphilic behaviour and forms micellar assemblies with typical dimensions of 100 nm. The assemblies display unique, redox induced morphology change in water, investigated by dynamic light scattering and transmission electron microscopy. Paclitaxel and Nile Red were encapsulated in the micelles as model guest molecular payloads. Release of the guests with a high degree of profile control by varying the concentration of redox agents is presented.

AB - The synthesis and characterization of a novel redox responsive comb-copolymer consisting of a poly(ferrocenylsilane) backbone and N-dimethylethyl ammonium and N-dimethyldecyl ammonium substituents are reported. Due to the presence of the side groups featuring cationic amine as well as decyl hydrocarbon chains the comb copolymer exhibits amphiphilic behaviour and forms micellar assemblies with typical dimensions of 100 nm. The assemblies display unique, redox induced morphology change in water, investigated by dynamic light scattering and transmission electron microscopy. Paclitaxel and Nile Red were encapsulated in the micelles as model guest molecular payloads. Release of the guests with a high degree of profile control by varying the concentration of redox agents is presented.

KW - n/a OA procedure

U2 - 10.1039/C2JM15755A

DO - 10.1039/C2JM15755A

M3 - Article

VL - 22

SP - 6429

EP - 6435

JO - Journal of materials chemistry

JF - Journal of materials chemistry

SN - 0959-9428

IS - 13

ER -

Organometallic polymeric carriers for redox triggered release of molecular payloads

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