Organosilicon interaction with biological membranes

Pepijn Beekman; Agustin Enciso-Martinez; Sidharam Pujari; Han Zuilhof; Leon Terstappen; Cees Otto; Séverine Le Gac

Organosilicon interaction with biological membranes

Pepijn Beekman^*, Agustin Enciso-Martinez, Sidharam Pujari, Han Zuilhof, Leon Terstappen, Cees Otto, Séverine Le Gac

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

Abstract

Poly(dimethyl siloxane) (PDMS) is the number-one used material to produce microfluidic devices, under the assumption it is biocompatible. Other organosilicon compounds, including PDMS, are ubiquitous in daily use products such as cosmetics, pharmaceuticals and even food. Their approval in these applications is based on the notion that the substance is not absorbed systemically. Here, using a range of analytical techniques, we demonstrate that a range of organosilicon compounds do interact with cell membranes and models thereof.

Original language	English
Title of host publication	MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	The Chemical and Biological Microsystems Society
Pages	1035-1036
Number of pages	2
ISBN (Electronic)	9781733419017
Publication status	Published - 2020
Event	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24 https://microtas2020.org/

Conference

Conference	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated title	MicroTAS 2020
City	Virtual Event
Period	4/10/20 → 9/10/20
Internet address	https://microtas2020.org/

Keywords

Cell membranes
Lipid membranes
Polydimethylsiloxane
Toxicity

Cite this

@inproceedings{4d5dfcc228324cedafb99b40cb0bc5d7,

title = "Organosilicon interaction with biological membranes",

abstract = "Poly(dimethyl siloxane) (PDMS) is the number-one used material to produce microfluidic devices, under the assumption it is biocompatible. Other organosilicon compounds, including PDMS, are ubiquitous in daily use products such as cosmetics, pharmaceuticals and even food. Their approval in these applications is based on the notion that the substance is not absorbed systemically. Here, using a range of analytical techniques, we demonstrate that a range of organosilicon compounds do interact with cell membranes and models thereof.",

keywords = "Cell membranes, Lipid membranes, Polydimethylsiloxane, Toxicity",

author = "Pepijn Beekman and Agustin Enciso-Martinez and Sidharam Pujari and Han Zuilhof and Leon Terstappen and Cees Otto and {Le Gac}, S{\'e}verine",

year = "2020",

language = "English",

pages = "1035--1036",

booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "The Chemical and Biological Microsystems Society",

note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",

url = "https://microtas2020.org/",

}

Beekman, P, Enciso-Martinez, A, Pujari, S, Zuilhof, H, Terstappen, L , Otto, C & Le Gac, S 2020, Organosilicon interaction with biological membranes. in MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, pp. 1035-1036, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020, Virtual Event, 4/10/20.

Organosilicon interaction with biological membranes. / Beekman, Pepijn; Enciso-Martinez, Agustin; Pujari, Sidharam et al.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, 2020. p. 1035-1036.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Organosilicon interaction with biological membranes

AU - Beekman, Pepijn

AU - Enciso-Martinez, Agustin

AU - Pujari, Sidharam

AU - Zuilhof, Han

AU - Terstappen, Leon

AU - Otto, Cees

AU - Le Gac, Séverine

N1 - Conference code: 24

PY - 2020

Y1 - 2020

N2 - Poly(dimethyl siloxane) (PDMS) is the number-one used material to produce microfluidic devices, under the assumption it is biocompatible. Other organosilicon compounds, including PDMS, are ubiquitous in daily use products such as cosmetics, pharmaceuticals and even food. Their approval in these applications is based on the notion that the substance is not absorbed systemically. Here, using a range of analytical techniques, we demonstrate that a range of organosilicon compounds do interact with cell membranes and models thereof.

AB - Poly(dimethyl siloxane) (PDMS) is the number-one used material to produce microfluidic devices, under the assumption it is biocompatible. Other organosilicon compounds, including PDMS, are ubiquitous in daily use products such as cosmetics, pharmaceuticals and even food. Their approval in these applications is based on the notion that the substance is not absorbed systemically. Here, using a range of analytical techniques, we demonstrate that a range of organosilicon compounds do interact with cell membranes and models thereof.

KW - Cell membranes

KW - Lipid membranes

KW - Polydimethylsiloxane

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=85098244872&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85098244872

SP - 1035

EP - 1036

BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - The Chemical and Biological Microsystems Society

T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020

Y2 - 4 October 2020 through 9 October 2020

ER -

Organosilicon interaction with biological membranes

Abstract

Conference

Keywords

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