Organosilicon interaction with biological membranes

Pepijn Beekman*, Agustin Enciso-Martinez, Sidharam Pujari, Han Zuilhof, Leon Terstappen, Cees Otto, Séverine Le Gac

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Poly(dimethyl siloxane) (PDMS) is the number-one used material to produce microfluidic devices, under the assumption it is biocompatible. Other organosilicon compounds, including PDMS, are ubiquitous in daily use products such as cosmetics, pharmaceuticals and even food. Their approval in these applications is based on the notion that the substance is not absorbed systemically. Here, using a range of analytical techniques, we demonstrate that a range of organosilicon compounds do interact with cell membranes and models thereof.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherThe Chemical and Biological Microsystems Society
Pages1035-1036
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020 - Virtual Event
Duration: 4 Oct 20209 Oct 2020
Conference number: 24
https://microtas2020.org/

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020
Abbreviated titleMicroTAS 2020
CityVirtual Event
Period4/10/209/10/20
Internet address

Keywords

  • Cell membranes
  • Lipid membranes
  • Polydimethylsiloxane
  • Toxicity

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