Oscillations in subthalamic nucleus measured by multi electrode arrays

J. Stegenga, Tjitske Heida

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    21 Downloads (Pure)

    Abstract

    The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.
    Original languageUndefined
    Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing
    EditorsP D Bamidis, S Th Konstantindis, K Bliznikova, N Pallikaris
    Publisherhellenic society of biomedical engineering (elevit)
    Pages784-787
    Number of pages4
    ISBN (Print)978-960-99365-0-7
    DOIs
    Publication statusPublished - 27 May 2010
    EventXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece
    Duration: 27 May 201030 May 2010
    Conference number: 12
    http://www.medicon2010.org/

    Publication series

    NameIFMBE Proceedings
    PublisherInternational Federation for Medical and Biological Engineering
    Number29
    ISSN (Print)1433-9277

    Conference

    ConferenceXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
    Abbreviated titleMEDICON 2010
    CountryGreece
    CityChalcidice
    Period27/05/1030/05/10
    Other27-30 May 2010
    Internet address

    Keywords

    • IR-72159
    • brain slices
    • oscillatory activity
    • Parkinson’s disease
    • METIS-270866
    • Multi-electrode arrays
    • EWI-18045

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