Oscillations in subthalamic nucleus measured by multi electrode arrays

J. Stegenga, Tjitske Heida

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)
11 Downloads (Pure)

Abstract

The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.
Original languageUndefined
Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing
EditorsP D Bamidis, S Th Konstantindis, K Bliznikova, N Pallikaris
Publisherhellenic society of biomedical engineering (elevit)
Pages784-787
Number of pages4
ISBN (Print)978-960-99365-0-7
DOIs
Publication statusPublished - 27 May 2010
EventXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece
Duration: 27 May 201030 May 2010
Conference number: 12
http://www.medicon2010.org/

Publication series

NameIFMBE Proceedings
PublisherInternational Federation for Medical and Biological Engineering
Number29
ISSN (Print)1433-9277

Conference

ConferenceXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
Abbreviated titleMEDICON 2010
CountryGreece
CityChalcidice
Period27/05/1030/05/10
Other27-30 May 2010
Internet address

Keywords

  • IR-72159
  • brain slices
  • oscillatory activity
  • Parkinson’s disease
  • METIS-270866
  • Multi-electrode arrays
  • EWI-18045

Cite this

Stegenga, J., & Heida, T. (2010). Oscillations in subthalamic nucleus measured by multi electrode arrays. In P. D. Bamidis, S. T. Konstantindis, K. Bliznikova, & N. Pallikaris (Eds.), XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 784-787). (IFMBE Proceedings; No. 29). hellenic society of biomedical engineering (elevit). https://doi.org/10.1007/978-3-642-13039-7_198
Stegenga, J. ; Heida, Tjitske. / Oscillations in subthalamic nucleus measured by multi electrode arrays. XII Mediterranean Conference on Medical and Biological Engineering and Computing. editor / P D Bamidis ; S Th Konstantindis ; K Bliznikova ; N Pallikaris. hellenic society of biomedical engineering (elevit), 2010. pp. 784-787 (IFMBE Proceedings; 29).
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title = "Oscillations in subthalamic nucleus measured by multi electrode arrays",
abstract = "The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.",
keywords = "IR-72159, brain slices, oscillatory activity, Parkinson’s disease, METIS-270866, Multi-electrode arrays, EWI-18045",
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Stegenga, J & Heida, T 2010, Oscillations in subthalamic nucleus measured by multi electrode arrays. in PD Bamidis, ST Konstantindis, K Bliznikova & N Pallikaris (eds), XII Mediterranean Conference on Medical and Biological Engineering and Computing. IFMBE Proceedings, no. 29, hellenic society of biomedical engineering (elevit), pp. 784-787, XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, Chalcidice, Greece, 27/05/10. https://doi.org/10.1007/978-3-642-13039-7_198

Oscillations in subthalamic nucleus measured by multi electrode arrays. / Stegenga, J.; Heida, Tjitske.

XII Mediterranean Conference on Medical and Biological Engineering and Computing. ed. / P D Bamidis; S Th Konstantindis; K Bliznikova; N Pallikaris. hellenic society of biomedical engineering (elevit), 2010. p. 784-787 (IFMBE Proceedings; No. 29).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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N2 - The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.

AB - The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.

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Stegenga J, Heida T. Oscillations in subthalamic nucleus measured by multi electrode arrays. In Bamidis PD, Konstantindis ST, Bliznikova K, Pallikaris N, editors, XII Mediterranean Conference on Medical and Biological Engineering and Computing. hellenic society of biomedical engineering (elevit). 2010. p. 784-787. (IFMBE Proceedings; 29). https://doi.org/10.1007/978-3-642-13039-7_198