Oscillations in subthalamic nucleus measured by multi electrode arrays

J. Stegenga; Tjitske Heida

doi:10.1007/978-3-642-13039-7_198

Oscillations in subthalamic nucleus measured by multi electrode arrays

J. Stegenga
, Tjitske Heida

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

2 Citations (Scopus)

113 Downloads (Pure)

Abstract

The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.

Original language	Undefined
Title of host publication	XII Mediterranean Conference on Medical and Biological Engineering and Computing
Editors	P D Bamidis, S Th Konstantindis, K Bliznikova, N Pallikaris
Publisher	hellenic society of biomedical engineering (elevit)
Pages	784-787
Number of pages	4
ISBN (Print)	978-960-99365-0-7
DOIs	https://doi.org/10.1007/978-3-642-13039-7_198
Publication status	Published - 27 May 2010
Event	XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 - Chalkidiki, Greece, Chalcidice, Greece Duration: 27 May 2010 → 30 May 2010 Conference number: 12 http://www.medicon2010.org/

Publication series

Name	IFMBE Proceedings
Publisher	International Federation for Medical and Biological Engineering
Number	29
ISSN (Print)	1433-9277

Conference

Conference	XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010
Abbreviated title	MEDICON 2010
Country/Territory	Greece
City	Chalcidice
Period	27/05/10 → 30/05/10
Other	27-30 May 2010
Internet address	http://www.medicon2010.org/

Keywords

IR-72159
brain slices
oscillatory activity
Parkinson’s disease
METIS-270866
Multi-electrode arrays
EWI-18045

Access to Document

10.1007/978-3-642-13039-7_198

Abstract_Stegenga_Medicon_2010

Cite this

Stegenga, J., & Heida, T. (2010). Oscillations in subthalamic nucleus measured by multi electrode arrays. In P. D. Bamidis, S. T. Konstantindis, K. Bliznikova, & N. Pallikaris (Eds.), XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 784-787). (IFMBE Proceedings; No. 29). hellenic society of biomedical engineering (elevit). https://doi.org/10.1007/978-3-642-13039-7_198

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Stegenga, J & Heida, T 2010, Oscillations in subthalamic nucleus measured by multi electrode arrays. in PD Bamidis, ST Konstantindis, K Bliznikova & N Pallikaris (eds), XII Mediterranean Conference on Medical and Biological Engineering and Computing. IFMBE Proceedings, no. 29, hellenic society of biomedical engineering (elevit), pp. 784-787, XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, Chalcidice, Greece, 27/05/10. https://doi.org/10.1007/978-3-642-13039-7_198

Oscillations in subthalamic nucleus measured by multi electrode arrays. / Stegenga, J.; Heida, Tjitske.
XII Mediterranean Conference on Medical and Biological Engineering and Computing. ed. / P D Bamidis; S Th Konstantindis; K Bliznikova; N Pallikaris. hellenic society of biomedical engineering (elevit), 2010. p. 784-787 (IFMBE Proceedings; No. 29).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.

AB - The subthalamic nucleus (STN) of the basal ganglia, is involved in the generation of Parkinsonian symptoms and forms one of the main targets for Deep Brain Stimulation (DBS). Effective frequencies of DBS are around 130 Hz. The effect of such stimuli in the STN is largely unknown but has been hypothesized to result in neuronal block, interrupting the pathophysiological oscillatory behavior which is observed in the Parkinsionian basal ganglia. Modelling studies suggest that synchronized oscillation at tremor (4-8 Hz) or beta (14-30 Hz) frequencies may occur. To study synchronicity of the STN in detail, we record action-potential activity from rat brain slices using multi electrode arrays (MEAs). These arrays consist of 60 recording sites and thus allow the study of spatio-temporal activity patterns. Here we show the characteristics of spike trains which we recorded in the STN.

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Stegenga J, Heida T. Oscillations in subthalamic nucleus measured by multi electrode arrays. In Bamidis PD, Konstantindis ST, Bliznikova K, Pallikaris N, editors, XII Mediterranean Conference on Medical and Biological Engineering and Computing. hellenic society of biomedical engineering (elevit). 2010. p. 784-787. (IFMBE Proceedings; 29). doi: 10.1007/978-3-642-13039-7_198